NCT04402424 (POCFIT) is a clinical trial of Faecal Immunochemical Testing in Colorectal Cancer, sponsored by Royal Surrey County Hospital NHS Foundation Trust.

Who is sponsoring NCT04402424?

NCT04402424 is sponsored by Royal Surrey County Hospital NHS Foundation Trust.

What drugs are being tested in NCT04402424?

Interventions in NCT04402424: Faecal Immunochemical Testing.

What condition does NCT04402424 study?

NCT04402424 studies Colorectal Cancer.

Is NCT04402424 still recruiting?

NCT04402424 is currently completed. Last updated 5 March 2021.

Last reviewed 2021-03-05 · How we verify

NCT04402424: POCFIT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Point of Care Faecal Immunochemical Testing for Colorectal Cancer

Completed Last updated 5 March 2021

What this trial tests

trial testing Faecal Immunochemical Testing in Colorectal Cancer in 631 participants. Completed in 16 August 2020.

Timeline

16 July 2019

Primary endpoint
16 August 2020

16 August 2020

Quick facts

Lead sponsor	Royal Surrey County Hospital NHS Foundation Trust
Status	Completed
Study type	OBSERVATIONAL
Enrollment	631
Start date	16 July 2019
Primary completion	16 August 2020
Estimated completion	16 August 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

Faecal Immunochemical Testing

Conditions studied

Colorectal Cancer — all drugs for Colorectal Cancer →

Sponsor

Royal Surrey County Hospital NHS Foundation Trust

Who can join

18 and older, any sex, with Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Blood that can be detected in stool via faecal immunochemical testing is a recognised risk factor for the presence of colorectal cancer. There are a number of point of care faecal immunochemical testing devices available. This study is to trial one of these machines into the clinical setting to see if the results are safe and accurate as a 'rule out' test for colorectal cancer. We will be investigating patients that present with symptoms or anaemia to their GP and are referred on the two-week rule pathway to our hospital. It has also been advocated that digital rectal examination (which is part of the routine assessment for a patient presenting to colorectal clinic) provides an opportunity to use a small sample of stool from a gloved finger to perform faecal immunochemical testing. We will be comparing a patient provided sample with a DRE sample on a standard laboratory-based machine.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Patient-reported outcome measures show FIT as an acceptable investigation to rule out colorectal cancer in the two-week wait cohort.
Maclean W, Whyte MB, Farkas N, Benton SC, et al · · 2023 · cited 3× · PMID 35639078 · DOI 10.1308/rcsann.2022.0025

Verify or expand the search:

Other recruiting trials for Colorectal Cancer

Currently open trials in the same condition.

NCT07152821 — Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcino · Phase 3 · recruiting
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NCT07523919 — Functional and Respiratory Determinants of Long-Term Colorectal Cancer Outcomes · recruiting
NCT07529301 — Functional and Respiratory Predictors of Early Postoperative Outcomes · recruiting

Other Royal Surrey County Hospital NHS Foundation Trust trials

Trials by the same sponsor.

NCT07210502 — Side Effects of Low Dose Rate Brachytherapy and Ultra-hypofractionated Radiotherapy in Low to Intermediate Risk Prostate · NA · not yet recruiting
NCT06638593 — MIRRORS-FROZEN - Comparing Open Vs Robotic Surgery in the Management of Women with Complex Pelvic Adnexal Masses ≤ 8cm. · NA · recruiting
NCT07046507 — The Exploratory Handheld Optical Coherence Tomography Study in Wilson's Disease · NA · completed
NCT06613256 — Characterisation of Endothelial Cells in Different Inflammatory Pathologies · recruiting
NCT06210724 — FIT in Diverticulitis · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04402424 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Royal Surrey County Hospital NHS Foundation Trust
Last refreshed: 5 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04402424.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing