NCT04400162

Augmentation of Depression Treatment by Gamified Network Retraining

Completed NA Last updated 28 April 2021

What this trial tests

NA trial testing Usability of the CCT in Depression Mild in 32 participants. Completed in 15 March 2021.

Timeline

14 May 2020

Primary endpoint
31 December 2020

15 March 2021

Quick facts

Lead sponsor	University Hospital Tuebingen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	32
Start date	14 May 2020
Primary completion	31 December 2020
Estimated completion	15 March 2021
Sites	1 location across Germany

Drugs / interventions tested

• Usability of the CCT
• Changes in regards to the depressive disorder

Conditions studied

• Depression Mild — all drugs for Depression Mild →
• Cognitive Impairment — all drugs for Cognitive Impairment →
• Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
• Depressive Disorder — all drugs for Depressive Disorder →

Sponsor

University Hospital Tuebingen

Who can join

18 and older, any sex, with Depression Mild or Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Major depressive disorder (MDD) is a highly prevalent and debilitating mental disorder with a high lifetime prevalence of 16-20%. Particularly for people with low socio-economic status, the existing and effective treatment options are hard to reach and show weaker effectivities. There is a potential to ameliorate depressive symptoms and improve quality of life in persons with mild-to-moderate depression by providing access to stimulating computerized trainings. Single computerized trainings that target depressive symptoms have been tested in laboratory and clinical settings so far. To date, innovative market access and confirmatory studies are missing for a large-scale implementation of such trainings. Thereby, the present work will foster a digitalized training paradigm (Paced-Auditory Serial Addition Task; PASAT) which was previously shown to reduce depressive symptoms, but in a novel innovative and gamified form on a tablet-PC handed out to participants. Different versions of the same training paradigm that comprise additional game elements will be compared. The feasibility study will gather data on effect size estimates of symptom severity reduction, user experience and usage in an ecological valid setting.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Gamification improves antidepressant effects of cognitive control training-A pilot trial.
   Weller S, Schroeder PA, Plewnia C. · · 2022 · cited 1× · PMID 36339520 · DOI 10.3389/fdgth.2022.994484