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Prevention of COVID19 Infection by the Administration of Hydroxychloroquine to Institutionalized Older People and Nursing Home Staff. Controlled Clinical Trial, Randomized Triple Blind by Clusters (PREVICHARM Study)
Professionals and residents of nursing homes are one of the most vulnerable groups in this public health crisis of COVID-19, since they have the highest rate of positives for COVID-19, despite the restriction measures carried out, such as prohibition of family visits to these centers, the infection occurs by cross transmission with the care staff of the centers, or with other residents. At the moment, there are no clinical trials to test the hypothesis that hydroxychloroquine is effective in coronavirus treatment. Although what has been observed is a better prognosis in infected patients, since this drug inhibits the replication of the virus and its expansion to other tissues. This study is a clinical trial to test the effectiveness of hydroxychloroquine as a preventive drug for SARS-CoV-2 infection. This drug will be applied to 1050 people residing in nursing home care and 880 professionals who work in close contact with these people and who have not yet contracted the infection. This project will be carried out in the territories of Madrid, Navarra, Aragon and Andalusia (Spain). Hydroxychloroquine is a widely known drug that is used in two scenarios, against autoimmune diseases, such as lupus or rheumatoid arthritis, and as an antimalarial drug. It is also intended to demonstrate that the presumed reduction in viral load that would be obtained with hydroxychloroquine prophylaxis, would have no effect in development of immunity against the virus. This fact can create a new paradigm for the de-escalation of the confinement to which the population has been subjected to stop the virus spread, allowing the development of general immunity in controlled populations until reaching total immunity. In addition to testing the effect of this drug, a non-pharmacological intervention based on a safety record will be tested in the management of infection on nursing home, to assess its effectiveness in detecting risk areas or bad practices carried out in this vulnerable environment. The study is led by researchers of the Institute of Biomedicine of Malaga (Spain), and has obtained a financing of 1,024,199 euros from Carlos III Health Institute (Spain). The period of execution of the clinical trial is one year, and with this intervention, the intention is to reduce cross-infection in residents by a minimum threshold of 15%, as well as to decrease infection in the professionals.
Details
| Lead sponsor | University of Malaga |
|---|---|
| Phase | Phase 2/Phase 3 |
| Status | UNKNOWN |
| Enrolment | 1930 |
| Start date | 2020-09 |
| Completion | 2021-04-01 |
Conditions
- Sars-CoV2
- Coronavirus Infection
- Prevention & Control
- Nursing Home
- Hydroxychloroquine
Interventions
- Hydroxychloroquine Only Product in Oral Dose Form
Primary outcomes
- Number of secondary cases of SARS-CoV2 infection among residents at six days — This outcome will be evaluated at six days from the administration of chemoprophylaxis with hydroxychloroquine
Discrete quantitative variable. Residents with active viral load (diagnosed by polymerase chain reaction test) will be considered infected. - Number of secondary cases of SARS-CoV2 infection among residents at 14 days — This outcome will be evaluated at 14 days from the administration of chemoprophylaxis with hydroxychloroquine
Discrete quantitative variable. Residents with active viral load (diagnosed by polymerase chain reaction test) will be considered infected. - Number of secondary cases of SARS-CoV2 infection among residents at 28 days — This outcome will be evaluated at 28 days from the administration of chemoprophylaxis with hydroxychloroquine
Discrete quantitative variable. Residents with active viral load (diagnosed by polymerase chain reaction test) will be considered infected. - SARS-CoV-2 infection in nursing home staff who provide direct care at six days — This outcome will be evaluated at six days from the administration of chemoprophylaxis with hydroxychloroquine
Dichotomous categorical variable - SARS-CoV-2 infection in nursing home staff who provide direct care at 14 days — This outcome will be evaluated at 14 days from the administration of chemoprophylaxis with hydroxychloroquine
Dichotomous categorical variable - SARS-CoV-2 infection in nursing home staff who provide direct care at 28 days — This outcome will be evaluated at 28 days from the administration of chemoprophylaxis with hydroxychloroquine
Dichotomous categorical variable