Who is sponsoring NCT04397588?

NCT04397588 is sponsored by Rennes University Hospital.

What condition does NCT04397588 study?

NCT04397588 studies ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2, Acute Refractory Heart Failure Related to SARS-CoV 2.

Is NCT04397588 still recruiting?

NCT04397588 is currently status unknown. Last updated 31 August 2020.

Last reviewed 2020-08-31 · How we verify

NCT04397588: ECMO-SARS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Extracorporeal Membrane Oxygenation (ECMO) and Coronavirus Disease (COVID) 19

Status unknown Last updated 31 August 2020

What this trial tests

trial in ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2 in 300 participants. Status unknown.

Timeline

21 April 2020

Primary endpoint
21 October 2020

21 October 2020

Quick facts

Lead sponsor	Rennes University Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	300
Start date	21 April 2020
Primary completion	21 October 2020
Estimated completion	21 October 2020
Sites	44 locations across France

Conditions studied

ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2 — all drugs for ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2 →
Acute Refractory Heart Failure Related to SARS-CoV 2 — all drugs for Acute Refractory Heart Failure Related to SARS-CoV 2 →

Sponsor

Rennes University Hospital

Who can join

Eligibility, any sex, with ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2 or Acute Refractory Heart Failure Related to SARS-CoV 2. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known. The present study will aim to report the results of the ECMO management of the most severe forms of COVID-19 through the first French ECMO registry.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation.
Massart N, Guervilly C, Mansour A, Porto A, et al · · 2023 · cited 29× · PMID 36519982 · DOI 10.1097/ccm.0000000000005714
Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.
Nesseler N, Fadel G, Mansour A, Para M, et al · · 2022 · cited 26× · PMID 35348610 · DOI 10.1097/aln.0000000000004168
Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study.
Nesseler N, Mansour A, Schmidt M, Para M, et al · · 2024 · cited 9× · PMID 38374103 · DOI 10.1186/s13054-024-04832-3

Verify or expand the search:

Other Rennes University Hospital trials

Trials by the same sponsor.

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NCT06950398 — Normothermic Oxygenated Perfusion (NMP) Viability Testing Before Transplantation of Discarded Livers · Phase 2 · not yet recruiting
NCT07188753 — Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-b · NA · not yet recruiting
NCT06898099 — Evaluation of the Efficacy of E2R Hypnotherapy in the Management of Chronic Insomnia in Primary Care (HypERR) · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04397588 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rennes University Hospital
Last refreshed: 31 August 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04397588.

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