NCT04395547

Safety and Efficacy of JointAlive™ on the Knee-joint Function in Adults With Knee Arthritis

Completed NA Last updated 23 December 2022

What this trial tests

NA trial testing JointAlive™ in Osteo Arthritis Knee in 72 participants. Completed in 27 May 2022.

Timeline

15 June 2020

Primary endpoint
27 May 2022

27 May 2022

Quick facts

Lead sponsor	Chenland Nutritionals Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	72
Start date	15 June 2020
Primary completion	27 May 2022
Estimated completion	27 May 2022
Sites	1 location across Canada

Drugs / interventions tested

• JointAlive™
• Placebo

Conditions studied

• Osteo Arthritis Knee — all drugs for Osteo Arthritis Knee →

Sponsor

Chenland Nutritionals Inc.

Who can join

Adults 40 to 75, any sex, with Osteo Arthritis Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Osteoarthritis (OA) is a joint disorder caused by wear and tear on the joint over time; as a result, the protective cartilage of the bone in the joint gradually wears down. The lifetime risk of developing OA in the knee, with symptoms such as pain, aching, and stiffness, is 40% in men and 47% in women. It is estimated that approximately 19% of Americans aged 45 and older are affected by knee OA. Knee OA accounts for 83% of the global burden caused by all OA types. Pain and stiffness in knees, a large weight-bearing joint, often leads to disability, which interferes with daily life activities and demands expensive medical treatments or care. Due to the limitations of current OA treatment methods, there is an increasing demand for effective and safer alternatives, such as natural health products with pain-relieving potential. The investigational product, JointAlive™, is a supplement designed to alleviate knee OA symptoms and to improve knee functionality. The present study will investigate the safety and efficacy of JointAlive™ in reducing knee OA symptoms and improving joint functionality in an otherwise healthy adult population with mild to moderate knee OA. JointAlive™ is a proprietary blend of Epimedium brevicornum Maxim leaves, Dioscorea nipponica Makino rhizome, Salvia miltoiorrhiza Bunge root and rhizome extracts

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A Randomized, Double-Blind, Placebo-Controlled Study Investigating the Safety and Efficacy of a Herbal Formulation on Knee Joint Function in Adults with Knee Osteoarthritis.
   Li L, Wang Y, Wang S, Zong J, et al · · 2025 · cited 1× · PMID 39400265 · DOI 10.1089/jicm.2023.0124