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NCT04394910
Impact of Antioxidant Juice Intake on Brain Injury and Placental Pathology in Infants With Intrauterine Growth Restriction (IUGR)
NA trial testing Pomegranate Juice in Intrauterine Growth Restriction in 103 participants. Completed in 26 February 2022.
1 January 2022
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 103 |
| Start date | 16 January 2016 |
| Primary completion | 1 January 2022 |
| Estimated completion | 26 February 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Pomegranate Juice
- Placebo Juice — full drug profile →
Conditions studied
- Intrauterine Growth Restriction — all drugs for Intrauterine Growth Restriction →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 45, female only, with Intrauterine Growth Restriction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Infants diagnosed with intrauterine growth restriction are at increased risk for brain injury in the neonatal period, and eventually increased risk for adverse long-term neurodevelopmental outcomes. This kind of growth restriction is often caused by long-term placental insufficiency leading to chronic lack of oxygen in the brain during development. Pomegranate juice is one of the highest polyphenol-containing dietary supplements commercially available. Previous studies have shown that pomegranate-derived polyphenols are potent neuroprotective antioxidants with no proven side effects. The investigators hypothesize that maternal dietary supplementation with pomegranate juice during the last trimester of pregnancy will reduce the effects of exogenous stimuli contributing to placental insufficiency, and will enhance brain growth and development in the IUGR population.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR.
Ross MM, Cherkerzian S, Mikulis ND, Turner D, et al · · 2021 · cited 14× · PMID 33574371 · DOI 10.1038/s41598-021-82144-0
Verify or expand the search:
- PubMed search for NCT04394910
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Pomegranate Juice
Trials testing the same drug.
- NCT04985630 — The Mitopure Challenge to Detect Levels of Urolithin A in Dried Blood Spots · NA · recruiting
- NCT04596254 — Detection of Gut Metabolites in Mother's Milk Following Juice Intake · NA · completed
- NCT04160312 — Mitopure™ (Proprietary Urolithin A) Bioavailability in Healthy Adults · NA · completed
- NCT04341961 — Effect of Pomegranate Juice Consumption on the Health of Mothers and Infants During Breastfeeding · NA · completed
- NCT03496584 — Effects of Phytonutrients on Vascular Health and Skin in Obese Males · NA · terminated
Other recruiting trials for Intrauterine Growth Restriction
Currently open trials in the same condition.
- NCT06534307 — Long-term Follow-up of Children Born in the PETN Studies · recruiting
- NCT06115122 — PEPPI Study: Identification of Women at Risk for Placental Dysfunction · recruiting
- NCT06074601 — MIRACLE of LIFE Study · active not recruiting
- NCT04766866 — sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term. · NA · recruiting
- NCT03398629 — Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies · recruiting
Other Brigham and Women's Hospital trials
Trials by the same sponsor.
- NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
- NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
- NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
- NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
- NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04394910 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 6 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04394910.
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