NCT04393519 (NEPTUN2) is a clinical trial of TIPS procedure in Portal Hypertension, sponsored by University Hospital, Bonn.

Who is sponsoring NCT04393519?

NCT04393519 is sponsored by University Hospital, Bonn.

What drugs are being tested in NCT04393519?

Interventions in NCT04393519: TIPS procedure.

What condition does NCT04393519 study?

NCT04393519 studies Portal Hypertension.

Is NCT04393519 still recruiting?

NCT04393519 is currently recruiting now. Last updated 5 October 2021.

Last reviewed 2021-10-05 · How we verify

NCT04393519: NEPTUN2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)

Recruiting now Last updated 5 October 2021

What this trial tests

trial testing TIPS procedure in Portal Hypertension in 1,000 participants. Currently enrolling.

Timeline

12 May 2020

Primary endpoint
31 December 2030

31 December 2030

Quick facts

Lead sponsor	University Hospital, Bonn
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,000
Start date	12 May 2020
Primary completion	31 December 2030
Estimated completion	31 December 2030
Sites	1 location across Germany

Drugs / interventions tested

TIPS procedure

Conditions studied

Portal Hypertension — all drugs for Portal Hypertension →

Sponsor

University Hospital, Bonn

Who can join

Adults 18 to 100, any sex, with Portal Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Cranial stent position is independently associated with the development of TIPS dysfunction.
Meyer C, Paar Pérez AM, Chang J, Sprinkart AM, et al · · 2022 · cited 9× · PMID 35241785 · DOI 10.1038/s41598-022-07595-5
Right Ventricular Contractility Predicts Clearance of Ascites After Transjugular Intrahepatic Portosystemic Shunt.
Heger LA, Chang J, Rohrer C, Reincke M, et al · · 2025 · cited 2× · PMID 41204773 · DOI 10.1111/liv.70422
Higher prevalence of cytomegalovirus and Epstein-Barr virus in acute-on-chronic liver failure.
Thiyagarajah K, Sonnenberg J, Görgülü E, Lembeck P, et al · · 2026 · PMID 41861678 · DOI 10.1016/j.jhepr.2025.101627

Verify or expand the search:

Other recruiting trials for Portal Hypertension

Currently open trials in the same condition.

NCT07439939 — Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Place · recruiting
NCT07521332 — Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis · Phase 4 · recruiting
NCT07419724 — Construction of a Portal Hypertension Biobank · recruiting
NCT07116096 — Effect of Handgrip Strength on Portal Vein Hemodynamics in Patients With Liver Cirrhosis · NA · recruiting
NCT07080697 — A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hyper · NA · recruiting

Other University Hospital, Bonn trials

Trials by the same sponsor.

NCT07291765 — Blood Flow Restriction Training in Acute Geriatric Rehabilitation: A Randomized Controlled Trial on Its Effects and Safe · NA · not yet recruiting
NCT07324330 — Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity · NA · recruiting
NCT07299591 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip I · recruiting
NCT07299565 — Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee · recruiting
NCT07043569 — Clinical-randomized Trial of the Effect of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04393519 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bonn
Last refreshed: 5 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04393519.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing