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NCT04391725
Guided Tissue Regeneration in Healing of Through and Through Periapical Lesion
NA trial testing Periapical surgery with guided tissue regeneration in Periapical Lesion in 32 participants. Status unknown.
11 December 2020
Quick facts
| Lead sponsor | Postgraduate Institute of Dental Sciences Rohtak |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 11 December 2019 |
| Primary completion | 11 December 2020 |
| Estimated completion | 11 April 2021 |
| Sites | 1 location across India |
Drugs / interventions tested
- Periapical surgery with guided tissue regeneration
- Periapical surgery without anyguided tissue regeneration
Conditions studied
- Periapical Lesion — all drugs for Periapical Lesion →
Sponsor
Postgraduate Institute of Dental Sciences Rohtak
Who can join
Adults 16 to 55, any sex, with Periapical Lesion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Aim of this study is to evaluate the effect of i-PRF in the healing of through and through periapical lesion after periradicular surgery
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Efficacy of mixture of injectable-platelet-rich fibrin and type-1 collagen particles on the closure of through-and-through periapical bone defects: A randomized controlled trial.
M A, S T, P S, A G. · · 2023 · cited 12× · PMID 37418583 · DOI 10.1111/iej.13954 -
Regenerative Medicine Advancements: A Systematic Review on the Combinatory Effect of Platelet-Rich Plasma/Fibrin and Collagen.
Gallo N, Kodra C, Rocco D, Saponaro C, et al · · 2026 · PMID 41532141 · DOI 10.1155/ijbm/1679626
Verify or expand the search:
- PubMed search for NCT04391725
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periapical Lesion
Currently open trials in the same condition.
- NCT06642415 — Effect Of High Magnification On Quality Of Life And Success After Endodontic Microsurgery: A Randomized Controlled Trial · NA · recruiting
Other Postgraduate Institute of Dental Sciences Rohtak trials
Trials by the same sponsor.
- NCT07412067 — Healing of Apicomarginal Defects Using Autograft or Allograft With Collagen Membrane · NA · not yet recruiting
- NCT07381595 — Role of Subgingival Instrumentation in Oral Lichen Planus · NA · not yet recruiting
- NCT07300124 — Outcome of Direct Pulp Capping and Partial Pulpotomy in Reversible Pulpitis · NA · not yet recruiting
- NCT07506135 — Effect of Aromatherapy on Pain and Anxiety During Orthodontic Extraction of Maxillary Premolars. · NA · completed
- NCT07179835 — To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04391725 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Postgraduate Institute of Dental Sciences Rohtak
- Last refreshed: 18 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04391725.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing