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NCT04390854
Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth
Phase 2 trial testing Blood clot scaffold in Pulp Necroses in 30 participants. Completed in 30 August 2020.
20 January 2020
Quick facts
| Lead sponsor | Nourhan M.Aly |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 6 July 2018 |
| Primary completion | 20 January 2020 |
| Estimated completion | 30 August 2020 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Blood clot scaffold — full drug profile →
- Blood clot scaffold combined with PRF — full drug profile →
Conditions studied
- Pulp Necroses — all drugs for Pulp Necroses →
Sponsor
Nourhan M.Aly — full company profile →
Who can join
Adults 8 to 18, any sex, with Pulp Necroses. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Assessment of volumetric changes after regenerative endodontic procedures using semiautomated and 3D U-NET automated CBCT segmentation: a retrospective cohort study.
Baraka M, El-Kateb N, Gamal M, Elwan AH, et al · · 2025 · cited 1× · PMID 40958117 · DOI 10.1186/s12903-025-06826-1
Verify or expand the search:
- PubMed search for NCT04390854
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pulp Necroses
Currently open trials in the same condition.
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- NCT06554366 — Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars · NA · recruiting
Other Nourhan M.Aly trials
Trials by the same sponsor.
- NCT06763419 — Internal Photobiomodulation For Management Of Temporomandibular Joint Internal Derangement · NA · recruiting
- NCT06146296 — THE EFFECT OF VITAMIN C ON POST-ORTHODONTIC TREATMENT RELAPSE · Phase 2, PHASE3 · unknown
- NCT05811728 — Three-dimensional Assessment of the Bone Changes Accompanying Laser-assisted Orthodontic Tooth Movement · NA · completed
- NCT06352658 — Efficacy of Different Treatments for Obstructive Sleep Apnea · NA · completed
- NCT05782088 — Single Versus Repeated Piezocision-assisted Orthodontic Tooth Movement · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04390854 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nourhan M.Aly
- Last refreshed: 4 November 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04390854.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing