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NCT04383704: MIND
MIND Diet Intervention and Cognitive Performance
NA trial testing New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND)) in Obesity in 37 participants. Completed in 20 March 2019.
20 March 2019
Quick facts
| Lead sponsor | Shiraz University of Medical Sciences |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 37 |
| Start date | 26 October 2018 |
| Primary completion | 20 March 2019 |
| Estimated completion | 20 March 2019 |
| Sites | 1 location across Iran |
Drugs / interventions tested
- New Dietary pattern ( Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND))
Conditions studied
- Obesity — all drugs for Obesity →
Sponsor
Shiraz University of Medical Sciences
Who can join
Adults 40 to 60, female only, with Obesity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This single-center, randomized trial examined the effect of MIND diet intervention on cognition and brain structure changes of healthy obese women over three months. The intervention group was lea to calorie-restricted modified by the MIND diet, and the control group received a calorie-restricted standard diet. The primary end-point was an assessment of cognitive performances measured with a comprehensive cognitive test battery. Secondary end-points were voxel-based morphometry to quantify the differences in brain structures. Our results revealed MIND diet could improve working memory, verbal recognition memory, and attention, more in comparison with the control group. Results also suggest that an increase in inferior frontal gyrus in the MIND diet group. Our study, for the first time, underlined that good adherence to the MIND diet as well as calorie restriction could reverse the destructive effect of obesity on cognition.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial.
Arjmand G, Abbas-Zadeh M, Eftekhari MH. · · 2022 · cited 79× · PMID 35190536 · DOI 10.1038/s41598-021-04258-9
Verify or expand the search:
- PubMed search for NCT04383704
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04383704 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shiraz University of Medical Sciences
- Last refreshed: 12 May 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04383704.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing