NCT04382781 (SAM-COVID) is a clinical trial of NO-Immunosuppressive in COVID-19 Infection, sponsored by Spanish Network for Research in Infectious Diseases.

Who is sponsoring NCT04382781?

NCT04382781 is sponsored by Spanish Network for Research in Infectious Diseases.

What drugs are being tested in NCT04382781?

Interventions in NCT04382781: NO-Immunosuppressive, Immunosuppressive, Immunoglubulins.

What condition does NCT04382781 study?

NCT04382781 studies COVID-19 Infection.

Is NCT04382781 still recruiting?

NCT04382781 is currently status unknown. Last updated 9 May 2020.

Last reviewed 2020-05-09 · How we verify

NCT04382781: SAM-COVID

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Immunosupressive Treatment in COVID-19 Patients Whit SAM-LIKE Profile: Retrospective Cohort Study (SAM-COVID Project)

Status unknown Last updated 9 May 2020

What this trial tests

trial testing NO-Immunosuppressive in COVID-19 Infection in 500 participants. Status unknown.

Timeline

1 May 2020

Primary endpoint
1 May 2020

1 May 2020

Quick facts

Lead sponsor	Spanish Network for Research in Infectious Diseases
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	500
Start date	1 May 2020
Primary completion	1 May 2020
Estimated completion	1 May 2020
Sites	1 location across Spain

Drugs / interventions tested

NO-Immunosuppressive — full drug profile →
Immunosuppressive
Immunoglubulins — full drug profile →

Conditions studied

COVID-19 Infection — all drugs for COVID-19 Infection →

Sponsor

Spanish Network for Research in Infectious Diseases

Who can join

18 and older, any sex, with COVID-19 Infection. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Invasive ventilation or death
Time frame: Up to 21 days
Days until invasive mechanical ventilation or death, whatever happened first.

Sponsor's own description

SAM-COVID is a retrospective cohort study that aims to determine the impact of immunosuppressive drugs and immunoglubulins in the outcome of patients with COVID-19.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19).
Rodríguez-Baño J, Pachón J, Carratalà J, Ryan P, et al · · 2021 · cited 86× · PMID 32860964 · DOI 10.1016/j.cmi.2020.08.010

Verify or expand the search:

Other recruiting trials for COVID-19 Infection

Currently open trials in the same condition.

NCT07013474 — A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · recruiting
NCT06965751 — A Study on the Effects in Healthy People of a New Drug Called PDI204 for Treating COVID-19 · Phase 1 · active not recruiting
NCT06923137 — A Study to Learn About How Well Yearly Updates to the COVID-19 Vaccine Work to Protect People From COVID-19 and How Much · active not recruiting
NCT05672355 — A Vaccine Booster (GEO-CM04S1) for the Prevention of COVID-19 in Patients With Chronic Lymphocytic Leukemia · Phase 2 · recruiting
NCT05774093 — Evaluation of COVID-19 Immune Barrier and Reinfection Risk · recruiting

Other Spanish Network for Research in Infectious Diseases trials

Trials by the same sponsor.

NCT03916224 — Adverse Events in the Tracheal Intubation in the Intensive Care Unit · completed
NCT03104933 — Proadrenomedullin and Copeptin in Patients With Septic Shock · completed
NCT02852902 — Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase- · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04382781 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Spanish Network for Research in Infectious Diseases
Last refreshed: 9 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04382781.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing