NCT04381637 (NIPESTIM) is a NA clinical trial of NIPE monitor in Anesthesia, sponsored by University Hospital, Lille.

Who is sponsoring NCT04381637?

NCT04381637 is sponsored by University Hospital, Lille.

What drugs are being tested in NCT04381637?

Interventions in NCT04381637: NIPE monitor, Tetanic stimulations.

What condition does NCT04381637 study?

NCT04381637 studies Anesthesia.

Is NCT04381637 still recruiting?

NCT04381637 is currently completed. Last updated 26 January 2023.

Last reviewed 2023-01-26 · How we verify

NCT04381637: NIPESTIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Newborn Infant Parasympathetic Evaluation (NIPE) Index After Standardized Tetanic Stimulations Under General Anesthesia

Completed NA Last updated 26 January 2023

What this trial tests

NA trial testing NIPE monitor in Anesthesia in 34 participants. Completed in 10 June 2021.

Timeline

28 January 2021

Primary endpoint
10 June 2021

10 June 2021

Quick facts

Lead sponsor	University Hospital, Lille
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	34
Start date	28 January 2021
Primary completion	10 June 2021
Estimated completion	10 June 2021
Sites	1 location across France

Drugs / interventions tested

NIPE monitor
Tetanic stimulations

Conditions studied

Anesthesia — all drugs for Anesthesia →

Sponsor

University Hospital, Lille

Who can join

Adults 6 to 10, any sex, with Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

NIPE monitor is the recently developed pediatric version of the ANI monitor, which is used in adults to monitor analgesia during general anesthesia. In adults, under general anesthesia, ANI decreases after a nociceptive stimulation. The amplitude of this decrease is related to the intensity of the stim. This study aims to investigate if NIPE index decreases in the same manner after stimulations in anesthetized children.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Quantitative assessment of a pediatric nociception monitor in children under sevoflurane anesthesia.
Lebrun S, Boccara J, Cailliau E, Herbet M, et al · · 2022 · cited 3× · PMID 35654480 · DOI 10.1136/rapm-2022-103547

Verify or expand the search:

Other trials of NIPE monitor

Trials testing the same drug.

NCT05758090 — Newborn Infant Parasympathetic Evaluation (NIPE) for Guiding Intraoperative Fentanyl in Children Under 2 Years · NA · completed

Other recruiting trials for Anesthesia

Currently open trials in the same condition.

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NCT07269808 — Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration · Phase 3 · recruiting
NCT07443254 — Prospective IR-led Sedation Feasibility · Phase 1, PHASE2 · recruiting

Other University Hospital, Lille trials

Trials by the same sponsor.

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NCT07408999 — Totally Versus Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer · NA · not yet recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04381637 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Lille
Last refreshed: 26 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04381637.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing