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NCT04381299
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
trial testing autologous platelet rich plasma in Infertility in 35 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2025
Quick facts
| Lead sponsor | ART Fertility Clinics LLC |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 35 |
| Start date | 25 April 2021 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across United Arab Emirates |
Drugs / interventions tested
- autologous platelet rich plasma — full drug profile →
- saline solution
Conditions studied
- Infertility — all drugs for Infertility →
- IVF — all drugs for IVF →
- Premature Ovarian Failure — all drugs for Premature Ovarian Failure →
- Anti-Mullerian Hormone Deficiency — all drugs for Anti-Mullerian Hormone Deficiency →
Sponsor
ART Fertility Clinics LLC
Who can join
Adults 18 to 40, female only, with Infertility or IVF. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention. To date, applications in orthopedics, wound healing, dermatology and plastic surgery have gained general acceptance, primarily as the role of platelets and their activation in tissue repair and recovery has become better understood at a cellular and molecular level. This study will involve adult women with a diagnosis of Premature ovarian insufficiency (POI) willing to perform an IVF/ICSI treatment.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction.
Wang X, Li J, Lu W, Gao F, et al · · 2024 · cited 8× · PMID 38654928 · DOI 10.3389/fendo.2024.1374382 -
Ovarian Aging: Mechanisms, Age-Related Disorders, and Therapeutic Interventions.
Liu X, Zhao Y, Feng Y, Wang S, et al · · 2025 · cited 3× · PMID 41256733 · DOI 10.1002/mco2.70481 -
Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis.
Liu F, Li J, Li J, Lan M, et al · · 2025 · PMID 41079455 · DOI 10.1016/j.reth.2025.09.010
Verify or expand the search:
- PubMed search for NCT04381299
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Infertility
Currently open trials in the same condition.
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Other ART Fertility Clinics LLC trials
Trials by the same sponsor.
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- NCT07093619 — Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Grad · NA · recruiting
- NCT06732843 — Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of · recruiting
- NCT07014267 — Virtual Reality for Mindfulness and Anxiety Reduction in Fertility Procedures · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04381299 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ART Fertility Clinics LLC
- Last refreshed: 19 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04381299.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing