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NCT04377880: ROSA
Development of Cellular Models for Osteoblast Response Study to Adipocytic Secretions in an Osteoporosis Context.
trial in Osteoporosis in 20 participants. Completed in 4 September 2024.
4 September 2024
Quick facts
| Lead sponsor | University Hospital, Lille |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 15 October 2020 |
| Primary completion | 4 September 2024 |
| Estimated completion | 4 September 2024 |
| Sites | 1 location across France |
Conditions studied
- Osteoporosis — all drugs for Osteoporosis →
Sponsor
University Hospital, Lille
Who can join
18 and older, any sex, with Osteoporosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The recent studies suggest that secretions from medullary adipocytes are involved in the mechanisms of bone loss in osteoporosis (OP) through their actions on neighbouring osteoforming cells, the osteoblasts. The objective of the research is the development of new cellular models representing the aging skeleton to confirm this hypothesis. To this end, osteoblasts will be isolated from human bone fragments coming from femoral heads discarded during total hip replacement surgery. The osteoblastic response to secreted factors released from medullary adipocytes of commercial origin will be analysed using conditioned media incubations. This phenotypic response will be quantified for each subject through the analysis of gene expression levels. Inter-subject phenotype variations will be related to bone density and microarchitecture data obtained by X-ray microtomography. This will assess the existence of a correlation between the osteoblast response to adipocyte secretions and the degree of osteoporosis of the subject from whom the cells are derived.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adipose tissue in bone regeneration - stem cell source and beyond.
Labusca L. · · 2022 · cited 9× · PMID 35949397 · DOI 10.4252/wjsc.v14.i6.372
Verify or expand the search:
- PubMed search for NCT04377880
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04377880 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Lille
- Last refreshed: 23 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04377880.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing