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NCT04377100
Impact on Anxiety and Motivation of COVID-19 and Predictors of Individual Responses
trial testing Computer task questionnaires in Anxiety in 2,962 participants. Completed in 19 November 2021.
1 May 2021
Quick facts
| Lead sponsor | National Institute of Mental Health (NIMH) |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 2,962 |
| Start date | 8 May 2020 |
| Primary completion | 1 May 2021 |
| Estimated completion | 19 November 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Computer task questionnaires
Conditions studied
- Anxiety — all drugs for Anxiety →
- Healthy Volunteers — all drugs for Healthy Volunteers →
Sponsor
National Institute of Mental Health (NIMH)
Who can join
18 and older, any sex, with Anxiety or Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Researchers think that people s mental health and behavior will be very affected by the steps taken to slow the spread of COVID-19, such as social distancing. Also, the threat of disease and death, to people and their loved ones, can cause much stress. Researchers want to learn more about these stressors and how they are affecting people. Objective: To study the relationship of affective, cognitive, and behavioral responses to stressors related to COVID-19 with neuroimaging and behavioral data collected before COVID-19. Eligibility: English-speaking adults age 18 and older Design: This online study will include both new participants and those who have taken part in past National Institute of Mental Health studies. All will complete the same surveys and tasks. Participants will give their name and email address. They will get a username and password. The file that links their username to their personal data will be kept secure. Participants will complete a set of surveys about the following: * Sociodemographic data, such age, race, and income * Education and work status * Mental and medical illness and treatment * Family medical history * Mood * COVID-19 experience * Anxiety * Substance and alcohol use * Attention control * Other mental health related topics. Participants will complete a finger-tapping task. For this, they will press a key a certain number of times in a limited period. They will get to practice the task. After the task, they will complete a survey about it. It will take about 1 hour to complete the surveys and the task. About 8 months later, participants will be contacted to repeat the surveys and task. Compensation is provided.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Sexual dimorphism in anxiety is programmed in-utero by sex-steroids: Proof of concept using a disease-model and stress responses to COVID pandemic.
Ernst M, Cogo-Moreira H, Desai J, Merke DP. · · 2024 · cited 1× · PMID 38064910 · DOI 10.1016/j.psychres.2023.115623 -
"Send My Information": Increasing public accessibility to clinical trials by facilitating participant expression of interest.
Dunkel L, Byrne LM, Olson E, Russell M, et al · · 2022 · cited 1× · PMID 35321223 · DOI 10.1017/cts.2022.19
Verify or expand the search:
- PubMed search for NCT04377100
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other National Institute of Mental Health (NIMH) trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04377100 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Mental Health (NIMH)
- Last refreshed: 31 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04377100.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing