NCT04376658 is a clinical trial of COVID-19 Severity in Quality of Life, sponsored by Hospital Moinhos de Vento.

Who is sponsoring NCT04376658?

NCT04376658 is sponsored by Hospital Moinhos de Vento.

What drugs are being tested in NCT04376658?

Interventions in NCT04376658: COVID-19 Severity.

What condition does NCT04376658 study?

NCT04376658 studies Quality of Life, Long-term Outcomes, Coronavirus Infection.

Is NCT04376658 still recruiting?

NCT04376658 is currently completed. Last updated 6 July 2022.

Last reviewed 2022-07-06 · How we verify

NCT04376658

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Quality of Life and Long-term Outcomes After Hospitalization for COVID-19

Completed Last updated 6 July 2022

What this trial tests

trial testing COVID-19 Severity in Quality of Life in 1,508 participants. Completed in 11 March 2022.

Timeline

15 July 2020

Primary endpoint
11 March 2022

11 March 2022

Quick facts

Lead sponsor	Hospital Moinhos de Vento
Status	Completed
Study type	OBSERVATIONAL
Enrollment	1,508
Start date	15 July 2020
Primary completion	11 March 2022
Estimated completion	11 March 2022
Sites	1 location across Brazil

Drugs / interventions tested

COVID-19 Severity

Conditions studied

Quality of Life — all drugs for Quality of Life →
Long-term Outcomes — all drugs for Long-term Outcomes →
Coronavirus Infection — all drugs for Coronavirus Infection →

Sponsor

Hospital Moinhos de Vento

Who can join

18 and older, any sex, with Quality of Life or Long-term Outcomes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present study aims to assess the determinants of health-related quality of life and long-term outcomes among survivors of hospitalization for Covid-19 in Brazil. The investigators will conduct a multicenter prospective cohort study nested in randomized clinical trials (coalition Covid-19 Brazil initiative) originally designed to assess the effects of specific Covid-19 treatments. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed up for a period of one year by means of structured telephone interviews. The primary outcome is one-year health-related quality of life assessed by the EQ-5D-3L. Secondary outcomes include all-cause mortality, rehospitalizations, return to work or study, physical functional status assessed by the Lawton \& Brody Instrumental Activities of Daily Living Scale, dyspnea assessed by the modified medical research council dyspnea scale, need of long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, and symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-revised.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study.
Rosa RG, Cavalcanti AB, Azevedo LCP, Veiga VC, et al · · 2023 · cited 48× · PMID 36594987 · DOI 10.1007/s00134-022-06953-1
Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII).
Rosa RG, Robinson CC, Veiga VC, Cavalcanti AB, et al · · 2021 · cited 5× · PMID 33886851 · DOI 10.5935/0103-507x.20210003
Brazilian battle against COVID-19
Dias F, Rosa R, Mendes C. · · 2021

Verify or expand the search:

Other recruiting trials for Quality of Life

Currently open trials in the same condition.

NCT07498959 — Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer · NA · recruiting
NCT07416448 — Neuroma-Associated Pain Management After Combat-Related Trauma in Ukraine · NA · recruiting
NCT07412379 — Predictive Factors for Functional and Quality of Life Decline in Patients >65 Years With a Gastrointestinal Tract Cancer · recruiting
NCT07380789 — Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine · NA · recruiting
NCT07280416 — Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer · recruiting

Other Hospital Moinhos de Vento trials

Trials by the same sponsor.

NCT07186517 — Genetic Variants in Stroke · not yet recruiting
NCT05996861 — Protocol For Sleep for Critically Ill Patients · unknown
NCT05306600 — Onco-Genomas Brasil: Mapping Breast and Prostate Cancer in the Brazilian Public Health System · recruiting
NCT05572736 — Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure · NA · completed
NCT06903260 — Robot-assisted Partial Nephrectomy With and Without Mixed Reality (REALITATEM Study) · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04376658 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Moinhos de Vento
Last refreshed: 6 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04376658.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing