NCT04376463

Effects of a Multicomponent Exercise and Supplementation of BCAA´s in Immunity System Dwelling Elderly

Status unknown NA Last updated 6 May 2020

What this trial tests

NA trial testing Branched Chain Aminoacid in Frail Elderly Syndrome in 50 participants. Status unknown.

Timeline

13 April 2019

Primary endpoint
14 September 2019

15 December 2020

Quick facts

Lead sponsor	University of Coimbra
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	50
Start date	13 April 2019
Primary completion	14 September 2019
Estimated completion	15 December 2020
Sites	1 location across Portugal

Drugs / interventions tested

• Branched Chain Aminoacid

Conditions studied

• Frail Elderly Syndrome — all drugs for Frail Elderly Syndrome →
• Physical Exercise — all drugs for Physical Exercise →

Sponsor

University of Coimbra

Who can join

65 and older, any sex, with Frail Elderly Syndrome or Physical Exercise. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The frailty syndrome (FS) is characterized by a multifactorial clinical syndrome, which includes 5 items, 1 - Change in body composition, 2 - Holding force, 3 - Fatigue reported, 4 - Reduction of walking speed, 5 - Low physical activity. The cumulative effect of deficits on the physiological functions caused by the syndrome results in early physical and cognitive loss. It is known that physical exercise, associated with protein supplementation are examples of non-pharmacological treatments that can promote functional and structural adaptive responses of the skeletal muscle system. One of the factors related to frailty is the reduction of body and muscle mass. Branched-chain amino acids, especially leucine, are nutrients that influence the adaptative response of muscle. It is intended through a physical exercise program (multicomponent = exercise of strength + aerobic exercise), to attenuate the effects of ageing and mainly of physical and cognitive frailty, evaluating the health parameters of frail elderly, alone or together with supplementation (BCAA), branched-chain amino acids, modulation of immune markers, markers of malnutrition and the skeletal muscle system in frail and pre-frail dwelling elderly people living in the city of Coimbra. To achieve that, the following parameters will be evaluated: biosocial indicators, anthropometric evaluation and body composition, indicators of global health and functional physical fitness, inflammatory biomarkers, neuroendocrine, signs of skeletal muscle function, evaluation of quality of life related to emotional state, cognitive profile and frailty-trait evaluation. The results obtained from the indicators, markers and questionnaires used are expected to contribute to the attenuation of frailty, improving the health and quality of life of the elderly.

Keywords: frail elderly, multicomponent exercise, branched chain amino acid, healthy life

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons.
   Caldo-Silva A, Furtado GE, Chupel MU, Bachi ALL, et al · · 2021 · cited 21× · PMID 33800577 · DOI 10.3390/nu13041106
2. Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers.
   Caldo-Silva A, Furtado GE, Chupel MU, Letieri RV, et al · · 2023 · cited 12× · PMID 37720080 · DOI 10.3389/fspor.2023.1171220
3. The Effect of a Resistance Training, Detraining and Retraining Cycle on Postural Stability and Estimated Fall Risk in Institutionalized Older Persons: A 40-Week Intervention.
   Rodrigues RN, Carballeira E, Silva F, Caldo-Silva A, et al · · 2022 · cited 5× · PMID 35627913 · DOI 10.3390/healthcare10050776