NCT04374006 is a EARLY_PHASE1 clinical trial of Dienogest in Endometriosis; Peritoneum, sponsored by Indonesia University.

Who is sponsoring NCT04374006?

NCT04374006 is sponsored by Indonesia University.

What drugs are being tested in NCT04374006?

Interventions in NCT04374006: Dienogest, Propolis, placebo.

What condition does NCT04374006 study?

NCT04374006 studies Endometriosis; Peritoneum, Endometriosis.

Is NCT04374006 still recruiting?

NCT04374006 is currently completed. Last updated 1 April 2021.

Last reviewed 2021-04-01 · How we verify

NCT04374006

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue

Completed EARLY_PHASE1 Last updated 1 April 2021

What this trial tests

EARLY_PHASE1 trial testing Dienogest in Endometriosis; Peritoneum in 120 participants. Completed in 18 May 2020.

Timeline

1 November 2019

Primary endpoint
18 May 2020

18 May 2020

Quick facts

Lead sponsor	Indonesia University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	120
Start date	1 November 2019
Primary completion	18 May 2020
Estimated completion	18 May 2020
Sites	1 location across Indonesia

Drugs / interventions tested

Dienogest (DIENOGEST) — full drug profile →
Propolis — full drug profile →
placebo

Conditions studied

Endometriosis; Peritoneum — all drugs for Endometriosis; Peritoneum →
Endometriosis — all drugs for Endometriosis →

Sponsor

Indonesia University

Who can join

Eligibility, female only, with Endometriosis; Peritoneum or Endometriosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluating inflammatory and apoptotic activity in rat's endometriosis lesion treated by Propolis compared to Dienogest

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Propolis and Their Active Constituents for Chronic Diseases.
Chavda VP, Chaudhari AZ, Teli D, Balar P, et al · · 2023 · cited 18× · PMID 36830794 · DOI 10.3390/biomedicines11020259
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor.
Situmorang H, Hestiantoro A, Purbadi S, Flamandita D, et al · · 2021 · cited 8× · PMID 34194730 · DOI 10.1016/j.amsu.2021.102459
Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model.
Situmorang H, Hestiantoro A, Purbadi S, Wuyung PE, et al · · 2023 · PMID 37753513 · DOI 10.1016/j.eurox.2023.100204

Verify or expand the search:

Other trials of Dienogest

Trials testing the same drug.

NCT06145438 — Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery · Phase 3 · completed
NCT05637073 — Effect of Management of the Endometrioma on Ovarian Reserve · unknown
NCT05697471 — Comparisons of the Therapeutic Effects of Dienogest and Danazol on Endometriosis · Phase 3 · unknown
NCT05272930 — The Effect of Dionegest Use on the Frequency of Fibromyalgia in Endometriosis · completed
NCT05751876 — Dienogest in Perimenopausal Women With Adenomyosis · completed

Other recruiting trials for Endometriosis; Peritoneum

Currently open trials in the same condition.

NCT06414083 — Histologic Comparison of Ablative Techniques for Endometriosis · NA · recruiting
NCT05162794 — Is Laparoscopic Excision for Peritoneal Endometriosis Helpful or Harmful? · NA · recruiting

Other Indonesia University trials

Trials by the same sponsor.

NCT07137130 — Secretome TGF Beta 3 · NA · not yet recruiting
NCT07420335 — Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy · NA · not yet recruiting
NCT07278284 — The Effectiveness of Press Needle Acupuncture on Preoperative Anxiety in Tympanoplasty and Mastoidectomy · NA · recruiting
NCT07337187 — Effect of Thread-Embedding Acupuncture at EX-B2 on Pain and Quality of Life in Chronic Low Back Pain · NA · not yet recruiting
NCT07242001 — Laser Acupuncture for Otitis Media With Effusion in Children · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04374006 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Indonesia University
Last refreshed: 1 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04374006.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing