NCT04371809 is a clinical trial of DNA methylome in Coronary Artery Disease, sponsored by University of Campania Luigi Vanvitelli.

Who is sponsoring NCT04371809?

NCT04371809 is sponsored by University of Campania Luigi Vanvitelli.

What drugs are being tested in NCT04371809?

Interventions in NCT04371809: DNA methylome.

What condition does NCT04371809 study?

NCT04371809 studies Coronary Artery Disease, Acute Coronary Syndrome, Atrial Fibrillation.

Is NCT04371809 still recruiting?

NCT04371809 is currently completed. Last updated 19 July 2022.

Last reviewed 2022-07-19 · How we verify

NCT04371809

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial

Completed Last updated 19 July 2022

What this trial tests

trial testing DNA methylome in Coronary Artery Disease in 100 participants. Completed in 20 March 2022.

Timeline

20 March 2019

Primary endpoint
1 March 2022

20 March 2022

Quick facts

Lead sponsor	University of Campania Luigi Vanvitelli
Status	Completed
Study type	OBSERVATIONAL
Enrollment	100
Start date	20 March 2019
Primary completion	1 March 2022
Estimated completion	20 March 2022
Sites	1 location across Italy

Drugs / interventions tested

DNA methylome

Conditions studied

Coronary Artery Disease — all drugs for Coronary Artery Disease →
Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
Atrial Fibrillation — all drugs for Atrial Fibrillation →

Sponsor

University of Campania Luigi Vanvitelli

Who can join

40 and older, any sex, with Coronary Artery Disease or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage useful in clinical practice. Moreover, these markers could be useful to predict the onset and severity of disease as well as to stratify stratification the prognostic risk during the follow-up. The aim of this project will be to evaluate the genome wide DNA methylation status in circulating CD4+ T cells and CD8+ T cells in patients with acute coronary syndromes (ACS), atrial fibrillation (AF) and with ACS in the presence of AF.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials.
Shi Y, Zhang H, Huang S, Yin L, et al · · 2022 · cited 233× · PMID 35752619 · DOI 10.1038/s41392-022-01055-2
ABCA1, TCF7, NFATC1, PRKCZ, and PDGFA DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome via network analysis.
Infante T, Franzese M, Ruocco A, Schiano C, et al · · 2022 · cited 19× · PMID 34151742 · DOI 10.1080/15592294.2021.1939481
CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation.
Infante T, Pepin ME, Ruocco A, Trama U, et al · · 2024 · cited 8× · PMID 37991085 · DOI 10.1111/eci.14135

Verify or expand the search:

Other recruiting trials for Coronary Artery Disease

Currently open trials in the same condition.

NCT07399002 — LONG NAGOMI™ PMCF STUDY · recruiting
NCT07420582 — Antegrade Autologous Blood Reinfusion After CPB · recruiting
NCT07493603 — A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease · Phase 1, PHASE2 · recruiting
NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting

Other University of Campania Luigi Vanvitelli trials

Trials by the same sponsor.

NCT07590349 — Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting · NA · not yet recruiting
NCT06718452 — Tinnitus and Treatment With umPEA-LUT · NA · not yet recruiting
NCT07124676 — Prospective Study Comparing Two Classification Systems for Second-degree Vaginal Tears During Spontaneous Childbirth to · not yet recruiting
NCT07425912 — Real-World Evaluation of TouchCare Nano in Pediatric Type 1 Diabetes · active not recruiting
NCT06991816 — The Brain&Senses Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04371809 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Campania Luigi Vanvitelli
Last refreshed: 19 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04371809.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing