NCT04369976 (GRACER1) is a NA clinical trial of ARTIFICIAL GRAVITY COMBINED WITH EXERCISE in Multiple Sclerosis, sponsored by Greek Aerospace Medical Association and Space Research.

Who is sponsoring NCT04369976?

NCT04369976 is sponsored by Greek Aerospace Medical Association and Space Research.

What drugs are being tested in NCT04369976?

Interventions in NCT04369976: ARTIFICIAL GRAVITY COMBINED WITH EXERCISE.

What condition does NCT04369976 study?

NCT04369976 studies Multiple Sclerosis, Stroke, Pulmonary Disease, Chronic Obstructive, Aged.

Is NCT04369976 still recruiting?

NCT04369976 is currently active, enrolled. Last updated 11 March 2025.

Last reviewed 2025-03-11 · How we verify

NCT04369976: GRACER1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Short Arm Human Centrifuge Therapeutic Training and Rehabilitation (GRACER1)

Active, enrolled NA Last updated 11 March 2025

What this trial tests

NA trial testing ARTIFICIAL GRAVITY COMBINED WITH EXERCISE in Multiple Sclerosis in 105 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 February 2020

Primary endpoint
1 March 2021

1 December 2025

Quick facts

Lead sponsor	Greek Aerospace Medical Association and Space Research
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	sequential
Masking	none
Primary purpose	prevention
Enrollment	105
Start date	1 February 2020
Primary completion	1 March 2021
Estimated completion	1 December 2025
Sites	1 location across Greece

Drugs / interventions tested

ARTIFICIAL GRAVITY COMBINED WITH EXERCISE

Conditions studied

Multiple Sclerosis — all drugs for Multiple Sclerosis →
Stroke — all drugs for Stroke →
Pulmonary Disease, Chronic Obstructive — all drugs for Pulmonary Disease, Chronic Obstructive →
Aged — all drugs for Aged →

Sponsor

Greek Aerospace Medical Association and Space Research

Who can join

Adults 17 to 90, any sex, with Multiple Sclerosis or Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is a single blind randomized controlled trial (RCT) designed to examine the benefit of a short arm human centrifuge intervention program (SAHC) combined with exercise, compared to a standard of care (SOC) rehabilitation program in physically impaired patients with MS, stroke, severe chronic obstructive pulmonary disease (COPD) and elderly people with balance and gait disorders (risk of falls).

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Gravity Threshold and Dose Response Relationships: Health Benefits Using a Short Arm Human Centrifuge.
Kourtidou-Papadeli C, Frantzidis CA, Gilou S, Plomariti CE, et al · · 2021 · cited 13× · PMID 34045973 · DOI 10.3389/fphys.2021.644661
Therapeutic Benefits of Short-Arm Human Centrifugation in Multiple Sclerosis-A New Approach.
Kourtidou-Papadeli C, Frantzidis CA, Bakirtzis C, Petridou A, et al · · 2021 · cited 7× · PMID 35058870 · DOI 10.3389/fneur.2021.746832
Rehabilitation assisted by Space technology-A SAHC approach in immobilized patients-A case of stroke.
Kourtidou-Papadeli C, Frantzidis C, Machairas I, Giantsios C, et al · · 2022 · cited 3× · PMID 36741804 · DOI 10.3389/fphys.2022.1024389

Verify or expand the search:

Other recruiting trials for Multiple Sclerosis

Currently open trials in the same condition.

NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04369976 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Greek Aerospace Medical Association and Space Research
Last refreshed: 11 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04369976.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing