Who is sponsoring NCT04369573?

NCT04369573 is sponsored by Niguarda Hospital.

What drugs are being tested in NCT04369573?

Interventions in NCT04369573: Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent.

What condition does NCT04369573 study?

NCT04369573 studies Cardiogenic Shock.

Is NCT04369573 still recruiting?

NCT04369573 is currently terminated. Last updated 23 October 2024.

Last reviewed 2024-10-23 · How we verify

NCT04369573: Altshock-2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock

Terminated Phase 4 Last updated 23 October 2024

What this trial tests

Phase 4 trial testing Early intra-aortic balloon pump (IABP) implantation in Cardiogenic Shock in 100 participants. Terminated before completion.

Timeline

4 May 2020

Primary endpoint
14 October 2024

14 October 2024

Quick facts

Lead sponsor	Niguarda Hospital
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	4 May 2020
Primary completion	14 October 2024
Estimated completion	14 October 2024
Sites	1 location across Italy

Drugs / interventions tested

Early intra-aortic balloon pump (IABP) implantation
Standard of care as vasoactive agent

Conditions studied

Cardiogenic Shock — all drugs for Cardiogenic Shock →

Sponsor

Niguarda Hospital

Who can join

Adults 18 to 75, any sex, with Cardiogenic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the study is to demonstrate the superiority of early intra-aortic balloon pump implantation at admission over local clinical practice (pharmacological only) in acute decompensated heart failure patients with cardiogenic shock, with respect to 60-day survival or successful bridge to heart replacement therapies (heart transplant or Left Ventricular Assist Device implantation).

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Contemporary approach to cardiogenic shock care: a state-of-the-art review.
Mehta A, Vavilin I, Nguyen AH, Batchelor WB, et al · · 2024 · cited 27× · PMID 38545346 · DOI 10.3389/fcvm.2024.1354158
Research Priorities in Critical Care Cardiology: JACC Expert Panel.
Miller PE, Huber K, Bohula EA, Krychtiuk KA, et al · · 2023 · cited 24× · PMID 38057075 · DOI 10.1016/j.jacc.2023.09.828
Early Intra-Aortic Balloon Support for Heart Failure-Related Cardiogenic Shock: A Randomized Clinical Trial.
Morici N, Sacco A, Frea S, Rota M, et al · · 2025 · cited 19× · PMID 40162941 · DOI 10.1016/j.jacc.2025.03.003
Advanced heart failure: from definitions to therapeutic options.
Garascia A, Palazzini M, Tedeschi A, Sacco A, et al · · 2023 · cited 14× · PMID 37125285 · DOI 10.1093/eurheartjsupp/suad028
Left Ventricular Mechanical Circulatory Support Devices for Cardiogenic Shock After Myocardial Infarction.
Giao DM, Giugliano RP. · · 2025 · cited 2× · PMID 40343681 · DOI 10.1007/s40119-025-00413-9
The management of heart failure cardiogenic shock: an international RAND appropriateness panel.
Williams S, Kalakoutas A, Olusanya S, Schrage B, et al · · 2024 · cited 2× · PMID 38566212 · DOI 10.1186/s13054-024-04884-5
Glimpse into the future.
Moller JE, Mangner N, Pappalardo F, Thiele H. · · 2023 · cited 1× · PMID 38093769 · DOI 10.1093/eurheartjsupp/suad133

Verify or expand the search:

Other recruiting trials for Cardiogenic Shock

Currently open trials in the same condition.

NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07345559 — Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock · NA · recruiting
NCT07374289 — On Scene ECPR in Ostrava · NA · recruiting
NCT07402018 — Intra-aortic Balloon Counterpulsation (IABC) Compliance · recruiting
NCT07309029 — Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR · recruiting

Other Niguarda Hospital trials

Trials by the same sponsor.

NCT05105399 — Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures · NA · not yet recruiting
NCT07153224 — The MICROSCOPE Project · not yet recruiting
NCT04763993 — Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study · NA · not yet recruiting
NCT07432347 — Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches · recruiting
NCT07234409 — Clinical Trial Addressing the Best Surgical Approach for Partial Nephrectomy With Single Port Robotic System in the Mana · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04369573 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Niguarda Hospital
Last refreshed: 23 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04369573.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing