Who is sponsoring NCT04368000?

NCT04368000 is sponsored by University of Utah.

What drugs are being tested in NCT04368000?

Interventions in NCT04368000: Intermittent prone positioning instructions, Usual care positioning with no instructions.

What condition does NCT04368000 study?

NCT04368000 studies Respiratory Failure, COVID-19.

Is NCT04368000 still recruiting?

NCT04368000 is currently terminated. Last updated 3 December 2020.

Last reviewed 2020-12-03 · How we verify

NCT04368000: PAPR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prone Positioning in Awake Patients With COVID-19 Requiring Hospitalization

Terminated NA Last updated 3 December 2020

What this trial tests

NA trial testing Intermittent prone positioning instructions in Respiratory Failure in 30 participants. Terminated before completion.

Timeline

29 April 2020

Primary endpoint
6 August 2020

6 August 2020

Quick facts

Lead sponsor	University of Utah
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	29 April 2020
Primary completion	6 August 2020
Estimated completion	6 August 2020
Sites	1 location across United States

Drugs / interventions tested

Intermittent prone positioning instructions
Usual care positioning with no instructions

Conditions studied

Respiratory Failure — all drugs for Respiratory Failure →
COVID-19 — all drugs for COVID-19 →

Sponsor

University of Utah

Who can join

18 and older, any sex, with Respiratory Failure or COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Acute respiratory distress syndrome (ARDS) is a major complication among patients with severe disease. In a report of 138 patients with COVID-19, 20% developed ARDS at a median of 8 days after the onset of symptoms, with 12.3% of patients requiring mechanical ventilation. Efficacious therapies are desperately needed. Supportive care combined with intermittent prone positioning may improve outcomes. Prone positioning (PP) of patients with severe ARDS (when combined with other lung-protective ventilation strategies) is associated with a significant mortality benefit. In addition, PP for \>12 hours in severe ARDS is strongly recommended by clinical practice guidelines. The aim of this study is to compare the outcomes of prone positioning versus usual care positioning in non-intubated patients hospitalized for COVID-19.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Patient-directed Prone Positioning in Awake Patients with COVID-19 Requiring Hospitalization (PAPR).
Johnson SA, Horton DJ, Fuller MJ, Yee J, et al · · 2021 · cited 46× · PMID 33596394 · DOI 10.1513/annalsats.202011-1466rl
Outcomes Evaluated in Controlled Clinical Trials on the Management of COVID-19: A Methodological Systematic Review.
Mathioudakis AG, Fally M, Hashad R, Kouta A, et al · · 2020 · cited 14× · PMID 33333777 · DOI 10.3390/life10120350

Verify or expand the search:

Other recruiting trials for Respiratory Failure

Currently open trials in the same condition.

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NCT06591533 — The Effect of Music Therapy on Vital Signs and Heart Rate Variability of Pediatric Patients During the Extubation Proces · NA · recruiting

Other University of Utah trials

Trials by the same sponsor.

NCT07515755 — Supplemental Oxygen and Oxygen Desaturations in Colonoscopies · NA · not yet recruiting
NCT07225426 — Personalizing Financial Incentives · NA · recruiting
NCT06716411 — Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness · NA · recruiting
NCT07246538 — Positive Airway Pressure (PAP) System Evaluation in Volunteers · NA · not yet recruiting
NCT04208984 — Diversion Device With Breath Control · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04368000 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Utah
Last refreshed: 3 December 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04368000.

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