NCT04365920 (JCOIN-HUB) is a Phase 3 clinical trial of Recovery Management Checkups (RMC) in Opioid-use Disorder, sponsored by Chestnut Health Systems.

Who is sponsoring NCT04365920?

NCT04365920 is sponsored by Chestnut Health Systems.

What drugs are being tested in NCT04365920?

Interventions in NCT04365920: Recovery Management Checkups (RMC), RMC-Adaptive.

What condition does NCT04365920 study?

NCT04365920 studies Opioid-use Disorder.

Is NCT04365920 still recruiting?

NCT04365920 is currently active, enrolled. Last updated 6 April 2025.

Last reviewed 2025-04-06 · How we verify

NCT04365920: JCOIN-HUB

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Recovery Management Checkups for Opioid Use Disorder Experiment

Active, enrolled Phase 3 Last updated 6 April 2025

What this trial tests

Phase 3 trial testing Recovery Management Checkups (RMC) in Opioid-use Disorder in 455 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

29 August 2021

Primary endpoint
30 April 2025

30 June 2025

Quick facts

Lead sponsor	Chestnut Health Systems
Phase	Phase 3
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	455
Start date	29 August 2021
Primary completion	30 April 2025
Estimated completion	30 June 2025
Sites	1 location across United States

Drugs / interventions tested

Recovery Management Checkups (RMC)
RMC-Adaptive

Conditions studied

Opioid-use Disorder — all drugs for Opioid-use Disorder →

Sponsor

Chestnut Health Systems

Who can join

18 and older, any sex, with Opioid-use Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The experiment will be conducted in collaboration with 6 jails representing discrete geographic counties in Illinois and the opioid treatment providers (OTP) that serve them. It will compare a re-entry as usual control group with two experimental groups in terms of their impact on the OUD service cascade, as well as public health and public safety outcomes. Study recruitment sites are six jails that provide treatment with medication for opioid use disorder (MOUD) to inmates with OUD prior to their release. At the time of their release to the community, 750 men and women will be randomly assigned to 1 of 3 groups: a) a re-entry as usual control, b) RMC with monthly checkups for 3 months post-release followed by quarterly checkups up to 2 years, or c) an adaptive version of RMC (RMC-A) that includes a modified checkup schedule based on each individual's pattern of treatment need. All participants will complete research interviews at release and quarterly thereafter up to 2 years post-enrollment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Impact of social determinants on opioid use disorder treatment engagement after release from jail: a case note content analysis.
Bell JS, Dewey JM, Watson DP, Johnstone C, et al · · 2026 · PMID 42015302 · DOI 10.1186/s13722-026-00666-2

Verify or expand the search:

Other recruiting trials for Opioid-use Disorder

Currently open trials in the same condition.

NCT04783558 — Effective Caregiving for Neonatal Abstinence Syndrome: Testing an Instructional Mobile Technology Platform for High-Risk · NA · active not recruiting
NCT05011266 — Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder · Phase 2, PHASE3 · recruiting
NCT05039554 — Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment · NA · recruiting
NCT05033028 — Smartphones for Opiate Addiction Recovery · Phase 3 · recruiting
NCT04738825 — Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With Pr · NA · recruiting

Other Chestnut Health Systems trials

Trials by the same sponsor.

NCT06375551 — K-ORCA: Testing a Decision Support Tool and Group Process for Selecting Interventions · NA · recruiting
NCT07365293 — Testing Implementation Strategies to Scale-up a Multicomponent Continuum of Service Intervention for Families Involved i · NA · recruiting
NCT07218562 — PATH (Peer Advanced Training in Harm Reduction) to Reducing Burnout Among Peers Who Deliver Harm Reduction Services (R61 · Phase 2 · enrolling by invitation
NCT06852170 — Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prev · NA · recruiting
NCT06414993 — Leveraging Parents and Peers to Increase Recovery Capital in Emerging Adults · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04365920 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chestnut Health Systems
Last refreshed: 6 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04365920.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing