NCT04365335 (AUTONOMIC) is a clinical trial of Assessment of work-related stress in Occupational Stress, sponsored by Direction Centrale du Service de Santé des Armées.

Who is sponsoring NCT04365335?

NCT04365335 is sponsored by Direction Centrale du Service de Santé des Armées.

What drugs are being tested in NCT04365335?

Interventions in NCT04365335: Assessment of work-related stress, Saliva sample collection, Cardiac and electrodermal recordings, Assessment of behavioral response to emotional stimulation.

What condition does NCT04365335 study?

NCT04365335 studies Occupational Stress.

Is NCT04365335 still recruiting?

NCT04365335 is currently completed. Last updated 9 March 2021.

Last reviewed 2021-03-09 · How we verify

NCT04365335: AUTONOMIC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Stress Biomarkers Leading to Professional Burnout Among People Involved in a Mobile Intensive Care Unit During the COVID-19 Pandemic

Completed Last updated 9 March 2021

What this trial tests

trial testing Assessment of work-related stress in Occupational Stress in 50 participants. Completed in 12 June 2020.

Timeline

25 April 2020

Primary endpoint
12 June 2020

12 June 2020

Quick facts

Lead sponsor	Direction Centrale du Service de Santé des Armées
Status	Completed
Study type	OBSERVATIONAL
Enrollment	50
Start date	25 April 2020
Primary completion	12 June 2020
Estimated completion	12 June 2020
Sites	1 location across France

Drugs / interventions tested

Assessment of work-related stress
Saliva sample collection — full drug profile →
Cardiac and electrodermal recordings
Assessment of behavioral response to emotional stimulation

Conditions studied

Occupational Stress — all drugs for Occupational Stress →

Sponsor

Direction Centrale du Service de Santé des Armées — full company profile →

Who can join

Adults 18 to 60, any sex, with Occupational Stress. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is aiming at investigating whether professional burnout in people involved in the mobile intensive care unit (in French: Element Mobile de Réanimation, EMR) in Mulhouse (France) can be predicted upstream by a low mindfulness level (as a protective factor) or by a dysregulation of stress pathways with a high level of perceived stress towards an emotional event (psychological index of allostatic load), i.e. an early and silent dysfunctional physiological response (measured by the electrophysiological and biological measurements of allostasis load and parasympathetic brake). It is part of a global approach aiming at identifying levers to prevent the allostatic load of occupational stress related to large-scale health crises.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Influence of mindfulness and coping flexibility in the early phases of burnout development in intensive care unit healthcare workers during the COVID-19 pandemic.
Claverie D, Duffaud A, Pellissier S, Jacob S, et al · · 2025 · PMID 40839697 · DOI 10.1371/journal.pone.0328064

Verify or expand the search:

Other recruiting trials for Occupational Stress

Currently open trials in the same condition.

NCT07402187 — "Productivity Training and Job Stress Among Nurses" · NA · recruiting
NCT06875882 — Evaluating Occupational Stress in Surgeons and Musicians: A Multi-modal Pilot Study Using Wearable EEG, Biomarker Analys · recruiting
NCT06721312 — Continuous Heart Rate Variability Monitoring in Doctors; Understanding Patterns of Stress and Recovery and Their Relatio · recruiting

Other Direction Centrale du Service de Santé des Armées trials

Trials by the same sponsor.

NCT07352904 — Exploration Strategies in Night Vision Sensors · not yet recruiting
NCT07344493 — Average ANKLE GO Score in the Objective Functional Assessment of the Ankle in Healthy Military Personnel (ANKMIL) · completed
NCT06996275 — Attachment and Post-Traumatic Stress Disorder in Military Personnel: Characterization of the French Military Population, · not yet recruiting
NCT06490029 — Diagnostic of Various Ototoxicity Induced by Cancer Treatment · recruiting
NCT06174181 — Preventive TREatment of Dry Eye in Patients Receiving Repeated Intravitreal Injections for Age-related Macular Degenerat · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04365335 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Direction Centrale du Service de Santé des Armées
Last refreshed: 9 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04365335.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing