NCT04364113: MDRD

The Modification of Diet in Renal Disease Study

Completed Phase 3 Last updated 27 April 2020

What this trial tests

Phase 3 trial testing Usual Protein Diet in Chronic Renal Disease in 840 participants. Completed in 31 December 2000.

Timeline

1 January 1989

Primary endpoint
31 January 1993

31 December 2000

Quick facts

Lead sponsor	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	treatment
Enrollment	840
Start date	1 January 1989
Primary completion	31 January 1993
Estimated completion	31 December 2000

Drugs / interventions tested

• Usual Protein Diet
• Low Protein Diet
• Very Low Protein Diet
• Medications needed to maintain usual blood pressure — full drug profile →
• Medications needed to maintain low blood pressure — full drug profile →

Conditions studied

• Chronic Renal Disease — all drugs for Chronic Renal Disease →

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who can join

Adults 18 to 70, any sex, with Chronic Renal Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Modification of Diet in Renal Disease Trial is a multicenter randomized clinical trial for men and women aged 18-70 years with chronic renal disease who are not on dialysis and who have not had a kidney transplant. Study participants are randomized in a 2 × 2 factorial design to diets containing different amounts of protein and phosphorus and to two levels of blood pressure control. The prescribed modifications differ depending on the level of a patient's kidney function. The primary outcome variable to compare diet or blood pressure groups is each patient's slope (or the change) in glomerular filtration rate (GFR) with time.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.