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NCT04362358: REST
Online Cognitive Behavioral Therapy (CBT) for Stress Disorders in Health Workers Involved in the Care of Patients During the Covid-19 Epidemic
NA trial testing Online cognitive behavioral therapy (CBT) in Stress - Prevention of Sleep Disorders, PTSD and Depression in 156 participants. Completed in 1 September 2021.
1 September 2021
Quick facts
| Lead sponsor | University Hospital, Strasbourg, France |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 156 |
| Start date | 20 July 2020 |
| Primary completion | 1 September 2021 |
| Estimated completion | 1 September 2021 |
| Sites | 1 location across France |
Drugs / interventions tested
- Online cognitive behavioral therapy (CBT)
- Online bibliotherapy programme
Conditions studied
- Stress - Prevention of Sleep Disorders, PTSD and Depression — all drugs for Stress - Prevention of Sleep Disorders, PTSD and Depression →
Sponsor
University Hospital, Strasbourg, France
Who can join
Adults 18 to 70, any sex, with Stress - Prevention of Sleep Disorders, PTSD and Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Some preliminary epidemiological research conduct in China in health workers involved in the care of Covid-19 patients has shown high rates of depression (\>50%), generalized anxiety disorder (\>44%), insomnia (\>36%) and stress symptoms (\>73%), which negatively impact their well-being as well as their ability to work effectively . These rates were observed during the epidemic peak, but they can also have a long-term mental health effect, both individually, but also in a systemic manner , similar to what has been reported relative to the SARS-CoV-1 . Cognitive behavioral therapy (CBT) is recognized as an effective treatment for stress-reduction, as well as for the prevention of multiple mental health problems in at-risk individuals . Moreover, CBT has been found to be effective in brief online formats , which could make it feasible during the current Covid-19 epidemic. To our knowledge, there are no online CBT programmes targeting stress problems in health workers involved in the care of patients during the current epidemic context. The aim of our study is to evaluate the efficacy of the online CBT programme we have developped to specifically address immediate perceived stress in health workers, as well as the prevention of mental health problems at 3- and 6-months follow-up
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Interventions to support the resilience and mental health of frontline health and social care professionals during and after a disease outbreak, epidemic or pandemic: a mixed methods systematic review.
Pollock A, Campbell P, Cheyne J, Cowie J, et al · · 2020 · cited 412× · PMID 33150970 · DOI 10.1002/14651858.cd013779 -
Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: the REduction of STress (REST) study protocol for a randomized controlled trial.
Weiner L, Berna F, Nourry N, Severac F, et al · · 2020 · cited 80× · PMID 33087178 · DOI 10.1186/s13063-020-04772-7 -
Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults.
Simon N, Robertson L, Lewis C, Roberts NP, et al · · 2021 · cited 33× · PMID 34015141 · DOI 10.1002/14651858.cd011710.pub3 -
Efficacy of the my health too online cognitive behavioral therapy program for healthcare workers during the COVID-19 pandemic: A randomized controlled trial.
Mengin AC, Nourry N, Severac F, Berna F, et al · · 2024 · cited 8× · PMID 38617386 · DOI 10.1016/j.invent.2024.100736 -
Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: The REduction of STress (REST) study protocol for a randomized controlled trial
Weiner L, Berna F, Nourry N, Severac F, et al · · 2020 · DOI 10.21203/rs.3.rs-37423/v1
Verify or expand the search:
- PubMed search for NCT04362358
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04362358 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Strasbourg, France
- Last refreshed: 20 January 2026
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