Motor Unit Abnormalities After Experimentally Induced Sensitization

NCT04361149 PHASE4 COMPLETED

Central sensitization is a condition that represents a cascade of neurological adaptations, resulting in an amplification of nociceptive responses from noxious and non-noxious stimuli. This phenomenon presents itself in a vast majority of chronic pain syndromes. Previous evidence has shown that central sensitization results in afferent nociceptor and dorsal horn abnormalities; however, a link between whether this abnormality translates into motor output and more specifically, ventral horn abnormalities, needs to be further explored. Twenty participants were recruited and either a topical capsaicin or a placebo topical cream was applied to their back to induce a transient state of sensitization. Surface electromyography(sEMG) and intramuscular electromyography(iEMG) were used to record motor unit activity from the trapezius and infraspinatus muscles before and after application of capsaicin/placebo. Motor unit recruitment and variability were analyzed in the sEMG and iEMG respectively

Details

Lead sponsor	Toronto Rehabilitation Institute
Phase	PHASE4
Status	COMPLETED
Enrolment	23
Start date	Tue Oct 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Mar 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Central Sensitisation
• Motor Disorders

Interventions

• Capsaicin Topical Cream (0.075%)
• Delsys Trigno Galileo System
• Excaliber, Natus Medical
• Placebo Cream

Countries

Canada