NCT04360395

Igniting Mobility in Adolescents and Young Adults With Cerebral Palsy

Active, enrolled NA Last updated 29 September 2025

What this trial tests

NA trial testing Gait Therapy in Cerebral Palsy in 120 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

3 August 2020

Primary endpoint
31 May 2025

31 May 2026

Quick facts

Lead sponsor	Father Flanagan's Boys' Home
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	120
Start date	3 August 2020
Primary completion	31 May 2025
Estimated completion	31 May 2026
Sites	1 location across United States

Drugs / interventions tested

• Gait Therapy

Conditions studied

• Cerebral Palsy — all drugs for Cerebral Palsy →

Sponsor

Father Flanagan's Boys' Home

Who can join

Adults 13 to 18, any sex, with Cerebral Palsy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study design will consist of a cohort of adolescents and young adults with cerebral palsy (CP) that will undergo a gait training protocol. All participants will complete MEG or EEG baseline brain imaging measures of their sensorimotor cortical activity, MRI brain/spinal cord imaging (previous MRI or template brain may be substituted), neurophysiological tests of the spinal cord H-reflex, and a series of mobility clinical tests and cognitive tests. Participants with metal in their body that would interfere with the MEG (e.g., braces on teeth, permanent retainer) will not undergo the MEG tests but will undergo the EEG assessments. Those who complete the MEG assessments will not undergo the EEG assessments.

After completing the baseline tests, the participants with CP will undergo the therapeutic gait training. After completing all of the therapeutic gait training sessions, the participants with CP will repeat the same assessments that were completed at baseline.

Separately, a cohort of neurotypical adolescents and young adults will also complete the baseline assessments. The neurotypical participants will not undergo the therapeutic gait training, but will be used as a normative group for interpreting if the changes seen in the participants with CP after therapy are in fact moving the system toward a normative state.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Overground gait training improves the sensorimotor cortical dynamics and mobility of persons with cerebral palsy.
   Busboom MT, Spooner RK, Chinen LS, Baker SE, et al · · 2025 · PMID 41192147 · DOI 10.1016/j.nicl.2025.103901