NCT04359511 (CORTICOVIDHUGO) is a Phase 3 clinical trial of Prednisone in COVID-19, sponsored by University Hospital, Tours.

Who is sponsoring NCT04359511?

NCT04359511 is sponsored by University Hospital, Tours.

What drugs are being tested in NCT04359511?

Interventions in NCT04359511: Prednisone, Hydrocortisone.

Is NCT04359511 still recruiting?

NCT04359511 is currently withdrawn. Last updated 12 May 2021.

Last reviewed 2021-05-12 · How we verify

NCT04359511: CORTICOVIDHUGO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia

Withdrawn Phase 3 Last updated 12 May 2021

What this trial tests

Phase 3 trial testing Prednisone in COVID-19. Withdrawn.

Timeline

3 July 2020

Primary endpoint
3 July 2020

3 July 2020

Quick facts

Lead sponsor	University Hospital, Tours
Phase	Phase 3
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Start date	3 July 2020
Primary completion	3 July 2020
Estimated completion	3 July 2020

Drugs / interventions tested

Prednisone (prednisone) — full drug profile →
Hydrocortisone (hydrocortisone) — full drug profile →

Conditions studied

COVID-19 — all drugs for COVID-19 →

Sponsor

University Hospital, Tours

Who can join

18 and older, any sex, with COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To date, there is no efficient therapeutics to prevent or treat COVID-19 related pulmonary failure. Corticosteroids (CS) could be a helpful therapeutic. Retrospective reports suggested survival improvement in patients with acute respiratory distress syndrome (ARDS). CT scan for COVID19 hospitalized patients showed sometimes unusual aspects of pneumonia, suggestive of an organizing phase of diffuse alveolar damage (DAD). We hypothesize that, in the context of alveolar aggression induced by COVID-19, CT scan could help to individualize patients with a high probability of pulmonary organizing process who could benefit from CS treatment.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Systemic corticosteroids for the treatment of COVID-19.
Wagner C, Griesel M, Mikolajewska A, Mueller A, et al · · 2021 · cited 151× · PMID 34396514 · DOI 10.1002/14651858.cd014963
A review of potential suggested drugs for coronavirus disease (COVID-19) treatment.
Tarighi P, Eftekhari S, Chizari M, Sabernavaei M, et al · · 2021 · cited 80× · PMID 33482181 · DOI 10.1016/j.ejphar.2021.173890
A critical evaluation of glucocorticoids in the management of severe COVID-19.
Solinas C, Perra L, Aiello M, Migliori E, et al · · 2020 · cited 61× · PMID 32616381 · DOI 10.1016/j.cytogfr.2020.06.012
Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection.
Labò N, Ohnuki H, Tosato G. · · 2020 · cited 57× · PMID 32629875 · DOI 10.3390/cells9071583
The intersection of COVID-19 and cancer: signaling pathways and treatment implications.
Zong Z, Wei Y, Ren J, Zhang L, et al · · 2021 · cited 54× · PMID 34001144 · DOI 10.1186/s12943-021-01363-1
Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence.
Wagner C, Griesel M, Mikolajewska A, Metzendorf MI, et al · · 2022 · cited 44× · PMID 36385229 · DOI 10.1002/14651858.cd014963.pub2
Novel therapeutic approaches for treatment of COVID-19.
Hossein-Khannazer N, Shokoohian B, Shpichka A, Aghdaei HA, et al · · 2020 · cited 36× · PMID 32494931 · DOI 10.1007/s00109-020-01927-6
Therapeutic role of corticosteroids in COVID-19: a systematic review of registered clinical trials.
Raju R, V P, Biatris PS, J SJUC. · · 2021 · cited 32× · PMID 33754123 · DOI 10.1186/s43094-021-00217-3

Verify or expand the search:

Other trials of Prednisone

Trials testing the same drug.

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NCT07278856 — Ruxolitinib in Combination With CHOP Chemotherapy for the Treatment of Untreated Nodal T-Follicular Helper Cell Lymphoma · Phase 1 · not yet recruiting

Other recruiting trials for COVID-19

Currently open trials in the same condition.

NCT07183709 — Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults · Phase 1 · active not recruiting
NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting

Other University Hospital, Tours trials

Trials by the same sponsor.

NCT07452978 — Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence · Phase 2 · not yet recruiting
NCT07443800 — Comorbidity Between Attention Deficit Hyperactivity Disorder and Fibromyalgia · NA · not yet recruiting
NCT07251530 — Communication Enhancement Among Ventilated Patients in Intensive Care · not yet recruiting
NCT07189338 — Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation · NA · not yet recruiting
NCT07054112 — Efficacy of Live Online Course Mindfulness Program on Perceived Fatigue in Hemodialysis Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04359511 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Tours
Last refreshed: 12 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04359511.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing