NCT04357847 (Covid-Thelium) is a clinical trial in Covid-19, sponsored by University Hospital, Rouen.

Who is sponsoring NCT04357847?

NCT04357847 is sponsored by University Hospital, Rouen.

What condition does NCT04357847 study?

NCT04357847 studies Covid-19, Endothelial Dysfunction, Thrombosis, Critically Ill.

Is NCT04357847 still recruiting?

NCT04357847 is currently status unknown. Last updated 28 April 2021.

Last reviewed 2021-04-28 · How we verify

NCT04357847: Covid-Thelium

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection

Status unknown Last updated 28 April 2021

What this trial tests

trial in Covid-19 in 100 participants. Status unknown.

Timeline

9 April 2020

Primary endpoint
31 July 2021

31 August 2021

Quick facts

Lead sponsor	University Hospital, Rouen
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	100
Start date	9 April 2020
Primary completion	31 July 2021
Estimated completion	31 August 2021
Sites	1 location across France

Conditions studied

Covid-19 — all drugs for Covid-19 →
Endothelial Dysfunction — all drugs for Endothelial Dysfunction →
Thrombosis — all drugs for Thrombosis →
Critically Ill — all drugs for Critically Ill →

Sponsor

University Hospital, Rouen

Who can join

18 and older, any sex, with Covid-19 or Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management.
Abou-Ismail MY, Diamond A, Kapoor S, Arafah Y, et al · · 2020 · cited 465× · PMID 32788101 · DOI 10.1016/j.thromres.2020.06.029
Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19.
Elyaspour Z, Zibaeenezhad MJ, Razmkhah M, Razeghian-Jahromi I. · · 2021 · cited 11× · PMID 34693754 · DOI 10.1177/10760296211042940
Routine and Advanced Laboratory Tests for Hemostasis Disorders in COVID-19 Patients: A Prospective Cohort Study.
Billoir P, Leprêtre P, Thill C, Bellien J, et al · · 2022 · cited 7× · PMID 35268474 · DOI 10.3390/jcm11051383
Plasma metabolomics signatures predict COVID-19 patient outcome at ICU admission comparable to clinical scores.
Karvelsson ST, Besnier E, Vilhjálmsson AI, Molkhou C, et al · · 2025 · cited 1× · PMID 40319053 · DOI 10.1038/s41598-025-00373-z

Verify or expand the search:

Other recruiting trials for Covid-19

Currently open trials in the same condition.

NCT05943743 — Hiccups and Obstacles Of E-Learning Among Medical Sudents · recruiting
NCT04466683 — Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia · Phase 2 · active not recruiting
NCT04433364 — COPE - COVID-19 in Pregnancy and Early Childhood · active not recruiting
NCT04568148 — COVID-19 Biorepository · active not recruiting
NCT04360538 — Long Term Outcomes of Patients With COVID-19 · active not recruiting

Other University Hospital, Rouen trials

Trials by the same sponsor.

NCT07441564 — Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Jux · NA · not yet recruiting
NCT07535944 — Prospective Exploration of Vascular Complications Associated With the Use of Immune Checkpoint Inhibitors · not yet recruiting
NCT07464184 — Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension · NA · not yet recruiting
NCT07359885 — Prediction of Postoperative Pulmonary Complications in Thoracic Surgery · not yet recruiting
NCT07247500 — Impact of Reventilation After One-Lung Ventilation in Thoracic Surgery (OLVREEXP) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04357847 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Rouen
Last refreshed: 28 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04357847.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing