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NCT04351451
Hypomagnesemia and Hypocalcemia Association Following Thyroidectomy
trial testing thyroidectomy in Hypomagnesemia in 74 participants. Completed in 1 February 2020.
1 January 2020
Quick facts
| Lead sponsor | King Saud University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 74 |
| Start date | 1 January 2019 |
| Primary completion | 1 January 2020 |
| Estimated completion | 1 February 2020 |
| Sites | 1 location across Saudi Arabia |
Drugs / interventions tested
- thyroidectomy
Conditions studied
- Hypomagnesemia — all drugs for Hypomagnesemia →
- Hypocalcemia — all drugs for Hypocalcemia →
- Hypomagnesemia With Secondary Hypocalcemia — all drugs for Hypomagnesemia With Secondary Hypocalcemia →
Sponsor
King Saud University
Who can join
12 and older, any sex, with Hypomagnesemia or Hypocalcemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Magnesium plays a role in the active transport of calcium (Ca+2) and potassium ions across cell membranes. Most of it is intracellular or in the bone , however less than 1% of magnesium is in the blood serum. Hypoparathyroidism post thyroidectomy leads to acute Hypocalcemia that leads to hypomagnesemia. The relation of Ca+2 and magnesium (Mg+2) metabolism is complex and mainly related to the interaction of these cations with parathyroid post thyroidectomy. (Mg+2) is an essential regulator of Ca+2 flux and intracellular action of Ca+2. Hypomagnesaemia impairs hypocalcaemia induced PTH release, which is corrected rapidly after magnesium replacement. Attempting to correct only hypocalcemia may prolong symptoms. It is important to monitor both Ca+2 \& Mg+2 levels following thyroidectomy to facilitate prompt resolution of symptoms. Aim of the study: is to highlight the prevalence of hypomagnesemia following thyroidectomy and its association with hypocalcemia which mandate early recognition and treatment to prevent prolongation of hypocalcemia and permanent hypoparathyroidism Methods: IRB obtained (E20-4615) informed consent taken from all patient. This is prospective open Label observational study in patients underwent thyroidectomy .the study period was from January 2019 to January 2020. Total of 74 patients with normal renal function. Corrected serum Ca+2, magnesium, phosphate level and vitamin D level are all checked pre operatively and in the first post-operative day. Result: Post thyroidectomy 56.8% of patients had hypomagnesemia. 59.5.1% patients had hypocalcemia and 41.9% of patients had low both Ca+2 and Mg+2 (P=0.004) Conclusion: Hypocalcemia and hypomagnesemia following thyroidectomy is of multi factorial related mainly to Ca+2, Mg+2 interaction. Keywords: Hypomagnesemia. Hypocalcemia. Thyroidectomy
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Related trials
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Trials testing the same drug.
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- NCT04580199 — Surgical Versus Non Surgical Management of Thyroid Nodule · NA · unknown
- NCT02855866 — Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroi · NA · completed
Other recruiting trials for Hypomagnesemia
Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04351451 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King Saud University
- Last refreshed: 17 April 2020
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