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NCT04345328: IMPORTUNE
Impact of Bariatric Surgery on the Gut Environment
trial in Bariatric Surgery Candidate in 151 participants. Completed in 1 September 2021.
1 June 2021
Quick facts
| Lead sponsor | KU Leuven |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 151 |
| Start date | 23 March 2017 |
| Primary completion | 1 June 2021 |
| Estimated completion | 1 September 2021 |
| Sites | 1 location across Belgium |
Conditions studied
- Bariatric Surgery Candidate — all drugs for Bariatric Surgery Candidate →
Sponsor
KU Leuven — full company profile →
Who can join
Adults 18 to 80, any sex, with Bariatric Surgery Candidate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to investigate the impact of bariatric surgery on the gut health. Patients operated with Roux-en-Y gastric bypass or sleeve gastrectomy and obese patients who want too loose weight with a traditional weight-loss program, will be followed up for 1 year. In these patients, the investigators will measure toxicity parameters to understand better the health status of their colon after surgery. In a next phase, the measured toxicity will be linked with certain players that might cause this toxicity. Protein metabolites, formed from undigested protein by microbiota in the colon, are expected to be toxic agents for the colon. Therefore, the investigators will investigate the fate of ingested protein once the surgery patients are metabolically stabilized.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The role of obesity and bariatric surgery-induced weight loss in breast cancer.
Bohm MS, Sipe LM, Pye ME, Davis MJ, et al · · 2022 · cited 19× · PMID 35870055 · DOI 10.1007/s10555-022-10050-6 -
The impact of bariatric surgery on macronutrient malabsorption depends on the type of procedure.
Evenepoel C, Vandermeulen G, Luypaerts A, Vermeulen D, et al · · 2022 · cited 11× · PMID 36712518 · DOI 10.3389/fnut.2022.1028881
Verify or expand the search:
- PubMed search for NCT04345328
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other KU Leuven trials
Trials by the same sponsor.
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- NCT07476716 — Peer-modeled Intervention · NA · not yet recruiting
- NCT07534384 — Automated CPET Interpretation: International Validation Study · not yet recruiting
- NCT07419555 — Belgian Lung Function Study · recruiting
- NCT07295600 — Postprandial Effect of Isocaloric Challenge Meals Enriched With Indigenous Fruits and Vegetables on Glucose Metabolism i · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04345328 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by KU Leuven
- Last refreshed: 20 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04345328.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing