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NCT04345250
Bone Response to Exercise and Energy Restriction in Young Adults
NA trial testing Energy restriction in Bone Resorption in 12 participants. Suspended.
30 June 2026
Quick facts
| Lead sponsor | Brock University |
|---|---|
| Phase | NA |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 12 |
| Start date | 30 September 2025 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 January 2027 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Energy restriction
Conditions studied
- Bone Resorption — all drugs for Bone Resorption →
- Bone Loss — all drugs for Bone Loss →
Sponsor
Brock University
Who can join
Adults 20 to 25, any sex, with Bone Resorption or Bone Loss. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cycling is commonly questioned whether it provides adequate mechanical strain on bone as many elite cyclists have been found to have a low bone mass. However, it remains unclear if this is due to cycling or low energy availability. In addition, acute dietary energy restriction has been found to be accompanied by an imbalance in bone remodelling with reduced bone formation. The objective of this proposal is to examine whether short-term energy restriction leads to changes in markers of bone formation and resorption at rest and in response to cycling in young adults. Specifically, the study will examine changes in circulating bone markers in 15 males and females (ages 18-24) both at rest and following one 45-minute spinning class both before and after one week of restricted energy intake. Blood will be drawn at rest (pre-trial, fasted), and 3 times post-trial (5 min, 1h and 24h); then analysed for biochemical markers of bone formation (BAP and OPG) and resorption (CTX and RANKL) to assess the impact of energy restriction on bone at rest and in response to exercise. This innovative work has potential to make significant advances in understanding tissue growth and development in response to exercise and malnutrition.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04345250
- Europe PMC full search
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Other Brock University trials
Trials by the same sponsor.
- NCT06530394 — Effects of Increased Greek Yogurt Consumption in Senior Adults · NA · completed
- NCT04670133 — Inulin Supplementation During Sanative Therapy to Further Improve Periodontal Healing · NA · withdrawn
- NCT04380155 — Cycling Duration and Bone Markers in in Active Young Adults · NA · withdrawn
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- NCT03977922 — A Pilot Nutrition Program for Spinal Cord Injury and MS · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04345250 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brock University
- Last refreshed: 31 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04345250.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing