Last reviewed · How we verify
NCT04343443: AHF-CODE-R
Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation
NA trial testing Clinical examination centered on congestion in Acute Heart Failure in 200 participants. Currently enrolling.
21 August 2026
Quick facts
| Lead sponsor | Central Hospital, Nancy, France |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 200 |
| Start date | 21 August 2020 |
| Primary completion | 21 August 2026 |
| Estimated completion | 21 August 2028 |
| Sites | 1 location across France |
Drugs / interventions tested
- Clinical examination centered on congestion
- Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography
- Biological: Blood sample retrieved for biological assessment and biobanking
- Telephone interview
- Kansas City Cardiomyopathy Questionnaire (KCCQ)
Conditions studied
- Acute Heart Failure — all drugs for Acute Heart Failure →
Sponsor
Central Hospital, Nancy, France
Who can join
18 and older, any sex, with Acute Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure. The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
An integrated Biobank in the Swedish Heart Failure Registry-clinomics, proteomics, transcriptomics and genomics.
Hage C, Andersson T, Christersson C, Linde C, et al · · 2026 · PMID 41961636 · DOI 10.1093/eschf/xvag092
Verify or expand the search:
- PubMed search for NCT04343443
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Clinical examination centered on congestion
Trials testing the same drug.
- NCT05097898 — Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation · NA · recruiting
- NCT05089162 — CHF-COV Reduced (Chronic Heart Failure With Reduced Ejection Fraction - COngestion eValuation) · NA · recruiting
- NCT05089149 — Chronic Heart Failure - COngestion eValuation · NA · recruiting
- NCT04343430 — Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation · NA · recruiting
- NCT04332692 — Acute Heart Failure - COngestion Discharge Evaluation · NA · recruiting
Other recruiting trials for Acute Heart Failure
Currently open trials in the same condition.
- NCT06587854 — a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure · recruiting
- NCT07008365 — The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · recruiting
- NCT06465498 — Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography · NA · recruiting
- NCT06597331 — Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital · recruiting
- NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting
Other Central Hospital, Nancy, France trials
Trials by the same sponsor.
- NCT06452290 — PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder · NA · not yet recruiting
- NCT07518498 — Hypnosis During Mechanical Ventilation Weaning · NA · not yet recruiting
- NCT07471334 — Prospective Study of Postictal Psychotic Symptoms Occuring After Video-EEG Monitoring in Focal Epilepsies · NA · not yet recruiting
- NCT07414667 — Primary Sjögren's Syndrome: Impact of Quantitative Anti-Ro52 Antibody Analysis on Patient Prognosis and Stratification ( · not yet recruiting
- NCT07415759 — Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04343443 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central Hospital, Nancy, France
- Last refreshed: 5 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04343443.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing