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NCT04342806

Healthcare Worker Exposure Response and Outcomes (HERO) Registry Study, COVID-19

Completed Last updated 5 September 2023
What this trial tests

trial in Health Care Worker (HCW) in 51,466 participants. Completed in 30 September 2022.

Timeline
10 April 2020
Primary endpoint
30 September 2022
30 September 2022

Quick facts

Lead sponsorDuke University
StatusCompleted
Study typeOBSERVATIONAL
Enrollment51,466
Start date10 April 2020
Primary completion30 September 2022
Estimated completion30 September 2022
Sites1 location across United States

Conditions studied

Sponsor

Duke University

Who can join

Adults 18 to 110, any sex, with Health Care Worker (HCW) or COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The HERO Registry provides a resource for collecting information on Healthcare Workers (HCWs) currently working in the United States, and their families and communities. The overall goal of the Registry is to develop the infrastructure necessary to create and engage a community of people who may be eligible for participation in future research studies, including those of COVID-19 prophylaxis and treatment.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Impact of the Early Phase of the COVID-19 Pandemic on US Healthcare Workers: Results from the HERO Registry.
    Forrest CB, Xu H, Thomas LE, Webb LE, et al · · 2021 · cited 67× · PMID 33694071 · DOI 10.1007/s11606-020-06529-z
  2. Racial/Ethnic Disparities in Healthcare Worker Experiences During the COVID-19 Pandemic: An Analysis of the HERO Registry.
    Lusk JB, Xu H, Thomas LE, Cohen LW, et al · · 2022 · cited 21× · PMID 35265822 · DOI 10.1016/j.eclinm.2022.101314
  3. Gender and intention to leave healthcare during the COVID-19 pandemic among U.S. healthcare workers: A cross sectional analysis of the HERO registry.
    Apple R, O'Brien EC, Daraiseh NM, Xu H, et al · · 2023 · cited 17× · PMID 37327216 · DOI 10.1371/journal.pone.0287428
  4. Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ).
    Naggie S, Milstone A, Castro M, Collins SP, et al · · 2023 · cited 13× · PMID 36682681 · DOI 10.1016/j.ijid.2023.01.019
  5. Post-traumatic stress disorder symptoms among healthcare workers during the COVID-19 pandemic: Analysis of the HERO Registry.
    Rice EN, Xu H, Wang Z, Webb L, et al · · 2023 · cited 5× · PMID 37943749 · DOI 10.1371/journal.pone.0293392
  6. Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform.
    Friedland A, Hernandez AF, Anstrom KJ, Chen-Lim ML, et al · · 2021 · cited 5× · PMID 34371163 · DOI 10.1016/j.cct.2021.106525
  7. Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial (HERO-HCQ)
    Naggie S, Milstone A, Castro M, Collins SP, et al · · 2021 · cited 4× · DOI 10.1101/2021.08.19.21262275
  8. Burnout in modern-day health care: Where are we, and how can we markedly reduce it? A meta-narrative review from the EUREKA* project.
    Linzer M, O'Brien EC, Sullivan E, Rathert C, et al · · 2025 · cited 3× · PMID 39894947 · DOI 10.1097/hmr.0000000000000433

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