Who is sponsoring NCT04340921?

NCT04340921 is sponsored by Barts & The London NHS Trust.

What drugs are being tested in NCT04340921?

Interventions in NCT04340921: COVID-19 exposure.

What condition does NCT04340921 study?

NCT04340921 studies Cardiovascular Disease Acute, Cardiomyopathies, COVID.

Is NCT04340921 still recruiting?

NCT04340921 is currently withdrawn. Last updated 21 April 2023.

Last reviewed 2023-04-21 · How we verify

NCT04340921

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Role of Adaptive Immunity in COVID-19 Associated Myocardial Injury

Withdrawn Last updated 21 April 2023

What this trial tests

trial testing COVID-19 exposure in Cardiovascular Disease Acute. Withdrawn.

Timeline

14 May 2020

Primary endpoint
14 April 2023

14 April 2023

Quick facts

Lead sponsor	Barts & The London NHS Trust
Status	Withdrawn
Study type	OBSERVATIONAL
Start date	14 May 2020
Primary completion	14 April 2023
Estimated completion	14 April 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

COVID-19 exposure — full drug profile →

Conditions studied

Cardiovascular Disease Acute — all drugs for Cardiovascular Disease Acute →
Cardiomyopathies — all drugs for Cardiomyopathies →
COVID — all drugs for COVID →

Sponsor

Barts & The London NHS Trust — full company profile →

Who can join

18 and older, any sex, with Cardiovascular Disease Acute or Cardiomyopathies. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

COVID-19 is associated with complications including ARDS and myocardial injury, which informs prognosis and patient outcome. The laboratory plans to perform immunophenotyping of peripheral T-cells in patients with COVID-19 and complications (ARDS, ITU admission, myocardial injury) and map this against clinical patient outcomes. The aim is to determine if there is a specific T-cell immunophenotype associated with COVID-19 and/or complications, which can be used to inform prognosis and potential therapies.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

T-cell responses and therapies against SARS-CoV-2 infection.
Toor SM, Saleh R, Sasidharan Nair V, Taha RZ, et al · · 2021 · cited 158× · PMID 32935333 · DOI 10.1111/imm.13262
Cardiac involvement in the long-term implications of COVID-19.
Satterfield BA, Bhatt DL, Gersh BJ. · · 2022 · cited 101× · PMID 34686843 · DOI 10.1038/s41569-021-00631-3
Delayed-onset myocarditis following COVID-19.
Bajaj R, Sinclair HC, Patel K, Low B, et al · · 2021 · cited 55× · PMID 33617781 · DOI 10.1016/s2213-2600(21)00085-0

Verify or expand the search:

Other trials of COVID-19 exposure

Trials testing the same drug.

NCT04659759 — COVID-19 Pregnancy Related Immunological, Clinical and Epidemiological Factors and Perinatal Outcomes · completed

Other recruiting trials for Cardiovascular Disease Acute

Currently open trials in the same condition.

NCT07159269 — Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers · NA · recruiting
NCT07187947 — Cardiovascular Health of Transgender Individuals During the Gender-affirming Pathway · recruiting
NCT07253974 — Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observationa · recruiting

Other Barts & The London NHS Trust trials

Trials by the same sponsor.

NCT05753085 — Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment · NA · withdrawn
NCT07047235 — Substrate Remodelling and Targeted Ablation in AF · NA · recruiting
NCT06871215 — Inflammation and Infective Endocarditis · withdrawn
NCT07076524 — MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL) · recruiting
NCT06596486 — A Comparison of CoolStick With Ethyl Chloride for the Assessment of Light Touch · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04340921 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Barts & The London NHS Trust
Last refreshed: 21 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04340921.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing