NCT04335955

Platelet Indices in Prediction of Mortality in Critically Ill Septic Patients

Completed Last updated 24 November 2023

What this trial tests

trial in Platelet Indices in 54 participants. Completed in 30 November 2020.

Timeline

1 May 2020

Primary endpoint
31 October 2020

30 November 2020

Quick facts

Lead sponsor	Amany Faheem
Status	Completed
Study type	OBSERVATIONAL
Enrollment	54
Start date	1 May 2020
Primary completion	31 October 2020
Estimated completion	30 November 2020
Sites	1 location across Egypt

Conditions studied

• Platelet Indices — all drugs for Platelet Indices →
• Mortality — all drugs for Mortality →
• Sepsis — all drugs for Sepsis →

Sponsor

Amany Faheem

Who can join

Adults 18 to 65, any sex, with Platelet Indices or Mortality. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Platelets (PLT), a major and essential constituent of blood, plays an important role in physiological and pathological processes such as coagulation, thrombosis, inflammation and maintenance of vascular endothelial cells the integrity (1).

Platelet indices are a group of parameters that are used to measure the total amount of PLTs, PLTs morphology and proliferation kinetics (2).

The commonly used PLT indices include PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). The MPV refers to the ratio of PCT to PLT count. PDW is numerically equal to the coefficient of PLT volume variation, which is used to describe the dispersion of PLTs volume (3).

It is well known that platelet indices have been applied in the diagnosis of hematological system diseases. In recent years, it has been discovered that these indices are related to the severity of illness and patients' prognosis. Reduction in PLT count is an independent risk factor for critically ill patients in intensive care unit (4).

In addition, Acute Physiology and Chronic Health Evaluation II (APACHE II) System also includes thrombocytopenia as an independent risk factor for mortality (5).

In a recent research, it will be reported that MPV will be rising with interleukin-6 and C-reactive protein in septic premature infants. MPV has been used as predictor of many inflammatory diseases as MPV significantly higher on both day 1 and day 3 in neonatal sepsis (6).

In addition, in patients with cirrhosis and ascites, elevated PDW and MPV will be accurate diagnostic predictors for ascetic fluid infection (7).

MPV and PDW will be used as biomarkers predicting the development of postoperative sepsis in colorectal cancer patient (8).

All these evidences indicated that PLT indices will be considered as indicator in a series of diseases (9).

Advantages of platelet indices are simple, available, cheap tools and routinely done in the hospital laboratory in all critical ill patients and may be a useful, sensitive tool for diagnosis and monitoring these patients especially in limited resource countries as Egypt. However, whether PLT indices are correlated with procalcitonin in assessment the severity of illness is still under research in septic patients

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.