Last reviewed · How we verify
NCT04334629: LIBERATE
LIBERATE Trial in COVID-19
Withdrawn
Phase 4
Last updated 25 July 2023
What this trial tests
Phase 4 trial testing Ibuprofen in Coronavirus. Withdrawn.
Timeline
26 May 2020
Primary endpoint
25 May 2021
25 May 2021
25 September 2021
Quick facts
| Lead sponsor | King's College London |
|---|---|
| Phase | Phase 4 |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Start date | 26 May 2020 |
| Primary completion | 25 May 2021 |
| Estimated completion | 25 September 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Ibuprofen (ibuprofen) — full drug profile →
Conditions studied
- Coronavirus — all drugs for Coronavirus →
- Respiratory Distress Syndrome — all drugs for Respiratory Distress Syndrome →
- SARS-CoV Infection — all drugs for SARS-CoV Infection →
Sponsor
King's College London
Who can join
18 and older, any sex, with Coronavirus or Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study aims to evaluate the reduction in severity and progression of lung injury with three doses of lipid ibuprofen in patients with SARS-CoV-2 infections.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Emerging treatment strategies for COVID-19 infection.
Gavriatopoulou M, Ntanasis-Stathopoulos I, Korompoki E, Fotiou D, et al · · 2021 · cited 209× · PMID 33128197 · DOI 10.1007/s10238-020-00671-y -
An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment.
Drożdżal S, Rosik J, Lechowicz K, Machaj F, et al · · 2021 · cited 186× · PMID 34991982 · DOI 10.1016/j.drup.2021.100794 -
Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies.
Market M, Angka L, Martel AB, Bastin D, et al · · 2020 · cited 115× · PMID 32655581 · DOI 10.3389/fimmu.2020.01512 -
Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives.
Sarkar C, Mondal M, Torequl Islam M, Martorell M, et al · · 2020 · cited 64× · PMID 33041814 · DOI 10.3389/fphar.2020.572870 -
Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.
Wick KD, Matthay MA, Ware LB. · · 2022 · cited 61× · PMID 36049490 · DOI 10.1016/s2213-2600(22)00058-3 -
The roles of lipids in SARS-CoV-2 viral replication and the host immune response.
Theken KN, Tang SY, Sengupta S, FitzGerald GA. · · 2021 · cited 59× · PMID 34599996 · DOI 10.1016/j.jlr.2021.100129 -
Widely available lysosome targeting agents should be considered as potential therapy for COVID-19.
Homolak J, Kodvanj I. · · 2020 · cited 54× · PMID 32522674 · DOI 10.1016/j.ijantimicag.2020.106044 -
NSAIDs and COVID-19: A Systematic Review and Meta-analysis.
Moore N, Bosco-Levy P, Thurin N, Blin P, et al · · 2021 · cited 44× · PMID 34339037 · DOI 10.1007/s40264-021-01089-5
Verify or expand the search:
- PubMed search for NCT04334629
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ibuprofen
Trials testing the same drug.
- NCT07401927 — Preemptive Analgesia in Laparoscopic Hysterectomy · not yet recruiting
- NCT07565012 — Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management · Phase 4 · completed
- NCT06671002 — Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial · Phase 4 · recruiting
- NCT06505148 — Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminop · Phase 4 · not yet recruiting
- NCT05935306 — Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery · NA · recruiting
Other recruiting trials for Coronavirus
Currently open trials in the same condition.
- NCT04772170 — Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies · recruiting
- NCT05868239 — Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study · NA · recruiting
- NCT04359836 — A Study to Explore the Role of Gut Flora in COVID-19 Infection · recruiting
- NCT04376034 — Convalescent Plasma Collection and Treatment in Pediatrics and Adults · Phase 3 · recruiting
- NCT04568148 — COVID-19 Biorepository · active not recruiting
Other King's College London trials
Trials by the same sponsor.
- NCT07357064 — Professional Decision Making in Childbirth. · not yet recruiting
- NCT07341087 — Skin Inflammation in Perimenopause: A Probiotic Intervention Proof of Concept Trial · NA · recruiting
- NCT07228962 — Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies · not yet recruiting
- NCT07365722 — Comparison of Two Non-surgical Procedure to Manage Gum Disease Around Implants. · NA · not yet recruiting
- NCT07378488 — Dance/Movement Therapy for Functional Neurological Disorder · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04334629 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King's College London
- Last refreshed: 25 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04334629.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing