Last reviewed · How we verify
NCT04328532: DIANE
MRI Screening of Placenta Adhesion Abnormalities
NA trial testing MRI in Placenta; Implantation in 71 participants. Currently enrolling.
21 October 2026
Quick facts
| Lead sponsor | Central Hospital, Nancy, France |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 71 |
| Start date | 21 October 2020 |
| Primary completion | 21 October 2026 |
| Estimated completion | 21 October 2026 |
| Sites | 1 location across France |
Drugs / interventions tested
- MRI — full drug profile →
Conditions studied
- Placenta; Implantation — all drugs for Placenta; Implantation →
Sponsor
Central Hospital, Nancy, France
Who can join
18 and older, female only, with Placenta; Implantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during delivery that increase the risk of intraoperative massive bleeding, hysterectomy and even maternal death. Ultrasound is the standard modality for diagnosing PAA, but Magnetic Resonance Imaging (MRI) has been increasingly performed in the case of inconclusive sonographic findings. However, standard morphological MRI sequences appear as insufficient to improve the sensitivity and specificity values for detecting PAA, while quantitative MRI may be more efficient. The main objective of this study is to characterize the diagnostic performance of quantitative MRI parameters (mainly Apparent Diffusion Coefficient, T2 and T2\*) reflecting placental perfusion and/or oxygenation at high field, without injection of gadolinium-based agent, for the detection of PAA in women with ongoing pregnancy between 30 and 38 weeks of gestation with risk factors for PPA.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Performance of antenatal imaging to predict placenta accreta spectrum degree of severity.
Morel O, van Beekhuizen HJ, Braun T, Collins S, et al · · 2021 · cited 21× · PMID 33811333 · DOI 10.1111/aogs.14112
Verify or expand the search:
- PubMed search for NCT04328532
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04328532 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central Hospital, Nancy, France
- Last refreshed: 13 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04328532.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing