Who is sponsoring NCT04328337?

NCT04328337 is sponsored by University of North Carolina, Chapel Hill.

What drugs are being tested in NCT04328337?

Interventions: Intralipid, 20% Intravenous Emulsion, Placebos.

What is the status of NCT04328337?

NCT04328337 is currently RECRUITING.

Last reviewed 2025-03-30 · How we verify

Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

NCT04328337 PHASE1, PHASE2 RECRUITING

The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are that this reduction is driven by elevated non esterified fatty acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.

Details

Lead sponsor	University of North Carolina, Chapel Hill
Phase	PHASE1, PHASE2
Status	RECRUITING
Enrolment	40
Start date	Tue Dec 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Jun 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Obesity

Interventions

Intralipid, 20% Intravenous Emulsion
Placebos

Countries

United States