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NCT04326998
Gutta-percha Solvent on Postoperative Pain After Root Canal Retreatment
NA trial testing solvent in Postoperative Pain in 60 participants. Completed in 18 June 2021.
18 March 2021
Quick facts
| Lead sponsor | Mahidol University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 18 September 2019 |
| Primary completion | 18 March 2021 |
| Estimated completion | 18 June 2021 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
- solvent
- non-solvent
Conditions studied
- Postoperative Pain — all drugs for Postoperative Pain →
- Root Canal — all drugs for Root Canal →
- Retreatment — all drugs for Retreatment →
Sponsor
Mahidol University
Who can join
18 and older, any sex, with Postoperative Pain or Root Canal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The process of non-surgical retreatment includes removing the previous root canal filling materials, disinfecting and sealing the root canal system to prevent re-infection. Gutta-percha is the most common root canal filling material used with various types of sealers. To remove gutta-percha, solvent has been suggested because of its ability to dissolve gutta-percha. The new formula, under the brand name, GuttaClear, has been investigated for its comparable dissolving ability and lower cytotoxicity when compared with others that are currently used. However, no information is currently available of GuttaClear solvent concerning postoperative pain. Therefore, the present study will evaluate postoperative pain after non-surgical retreatment cases using GuttaClear as a solvent compared with no solvent used. Sixty participants are chosen and distributed into 2 groups, randomly. After the procedures, participants will receive the questionnaires about postoperative pain and the amount of medication intake. Both will be recorded at six time periods: (1) immediately after procedure; (2) 6 hours after procedure; (3) 12 hours after procedure; (4) 24 hours after procedure; (5) 48 hours after procedure and (6) 72 hours after procedure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of GuttaClear on Postoperative Pain After Root Canal Retreatment: A Randomized Clinical Trial.
Sirijindamai D, Wichai W, Mitrirattanakul S, Jantarat J. · · 2023 · cited 3× · PMID 36748447 · DOI 10.14744/eej.2022.85047
Verify or expand the search:
- PubMed search for NCT04326998
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04326998 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mahidol University
- Last refreshed: 21 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04326998.
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