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NCT04326738
The Effect of Midazolam on Dexamethasone-induced Perineal Pruritus
EARLY_PHASE1 trial testing Midazolam in Pruritus in 90 participants. Completed in 30 December 2020.
30 April 2020
Quick facts
| Lead sponsor | Yangzhou University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 90 |
| Start date | 16 January 2020 |
| Primary completion | 30 April 2020 |
| Estimated completion | 30 December 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- Midazolam (midazolam) — full drug profile →
- normal saline
Conditions studied
- Pruritus — all drugs for Pruritus →
Sponsor
Yangzhou University
Who can join
Adults 18 to 65, any sex, with Pruritus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dexamethasone is commonly used in clinical practice.However, intravenous dexamethasone sodium phosphate may cause perineal discomfort.With the popularization of comfortable medical technology, patients have higher and higher requirements for comfortable medical treatment.Perineal pruritus caused by intravenous dexamethasone sodium phosphate may cause adverse physiological and psychological effects on patients and increase the incidence of unpleasant experiences during anesthesia.Therefore, it is very important to find a practical and effective method of inhibition.Midazolam is a water-soluble benzodiazepine commonly used in clinical practice, which has been proved to effectively inhibit the itching caused , while its effect on the itching caused by dexamethasone has not been reported.By observing the effect of pre-injection midazolam on the perineal itching caused by dexamethasone sodium phosphate, this experiment intends to preliminarily explore its possible mechanism .
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04326738
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Other recruiting trials for Pruritus
Currently open trials in the same condition.
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Other Yangzhou University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04326738 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yangzhou University
- Last refreshed: 10 February 2022
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