NCT04326075 (EC-COVID-RCT) is a NA clinical trial of CPAP treatment in CPAP Ventilation, sponsored by Mario Negri Institute for Pharmacological Research.

Who is sponsoring NCT04326075?

NCT04326075 is sponsored by Mario Negri Institute for Pharmacological Research.

What drugs are being tested in NCT04326075?

Interventions in NCT04326075: CPAP treatment.

What condition does NCT04326075 study?

NCT04326075 studies CPAP Ventilation, COVID-19, Emergency Departments.

Is NCT04326075 still recruiting?

NCT04326075 is currently completed. Last updated 19 December 2022.

Last reviewed 2022-12-19 · How we verify

NCT04326075: EC-COVID-RCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Early CPAP in COVID-19 Patients With Respiratory Failure.

Completed NA Last updated 19 December 2022

What this trial tests

NA trial testing CPAP treatment in CPAP Ventilation in 68 participants. Completed in 15 December 2022.

Timeline

1 December 2020

Primary endpoint
30 June 2021

15 December 2022

Quick facts

Lead sponsor	Mario Negri Institute for Pharmacological Research
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	68
Start date	1 December 2020
Primary completion	30 June 2021
Estimated completion	15 December 2022
Sites	1 location across Italy

Drugs / interventions tested

CPAP treatment

Conditions studied

CPAP Ventilation — all drugs for CPAP Ventilation →
COVID-19 — all drugs for COVID-19 →
Emergency Departments — all drugs for Emergency Departments →

Sponsor

Mario Negri Institute for Pharmacological Research

Who can join

Adults 18 to 70, any sex, with CPAP Ventilation or COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study aims at clarifying whether early treatment with continuous positive airway pressure (CPAP) ventilation is able to reduce the need for intubation or death in patients visiting an emergency department (ED) with known or suspected COVID-19 infection and insufficiency respiratory.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP).
Bassetti M, Giacobbe DR, Bruzzi P, Barisione E, et al · · 2021 · cited 29× · PMID 34328629 · DOI 10.1007/s40121-021-00487-7
COVID-19 Critical Illness: A Data-Driven Review.
Ginestra JC, Mitchell OJL, Anesi GL, Christie JD. · · 2022 · cited 24× · PMID 34520220 · DOI 10.1146/annurev-med-042420-110629
High-Flow Nasal Oxygen and Noninvasive Ventilation for COVID-19.
Al-Dorzi HM, Kress J, Arabi YM. · · 2022 · cited 4× · PMID 35667746 · DOI 10.1016/j.ccc.2022.01.006
Helmet Non-Invasive Ventilation for COVID-19 Patients (Helmet-COVID): study protocol for a multicentre randomised controlled trial.
Arabi YM, Tlayjeh H, Aldekhyl S, Al-Dorzi HM, et al · · 2021 · cited 4× · PMID 34446500 · DOI 10.1136/bmjopen-2021-052169
Noninvasive ventilation strategies for patients with severe or critical COVID-19: A rapid review of clinical outcomes
Kelly SE, Wells GA. · · 2022 · DOI 10.1101/2022.05.25.22275586
Helmet noninvasive ventilation for COVID-19 patients “Helmet-COVID”: study protocol for a multicenter randomized controlled trial
Arabi Y, Tlayjeh H, Aldekhyl S, Al-Dorzi HM, et al · · 2021 · DOI 10.1101/2021.08.04.21260420

Verify or expand the search:

Other trials of CPAP treatment

Trials testing the same drug.

NCT04251975 — Masked Hypertensive Patients With Obstructive Sleep Apnea · NA · completed
NCT03987425 — Normotensive OSA Patients With Nondipper Circadian Blood Pressure Pattern · NA · completed
NCT02954224 — Prevention Of Delirium in Elderly With Obstructive Sleep Apnea (PODESA) · NA · completed

Other Mario Negri Institute for Pharmacological Research trials

Trials by the same sponsor.

NCT07428018 — Pragmatic Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Onco · Phase 2 · not yet recruiting
NCT07331103 — RESOLving INflammation Through Diet for Health (RESOLVIN) · NA · recruiting
NCT06994468 — Effect of B-cell Depleting Therapies on PLA2R-specific B Cells in Patients With Membranous Nephropathy · NA · completed
NCT07111624 — A New Crowding Indicator in the Emergency Department · not yet recruiting
NCT07021118 — Mild TBI in the Emergency Department · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04326075 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mario Negri Institute for Pharmacological Research
Last refreshed: 19 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04326075.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing