NCT04325178: MASS

Mycoprotein as the Basis of a Sustainable Diet to Support Muscle Mass Maintenance and Reconditioning in Older Adults.

Completed NA Last updated 27 March 2020

What this trial tests

NA trial testing Protein, calorie and macronutrient controlled diet, derived from either omnivorous or non-animal sources, alongside unilateral resistance exercise, over a three-day period. in Aging in 19 participants. Completed in 31 January 2020.

Timeline

22 March 2018

Primary endpoint
13 September 2019

31 January 2020

Quick facts

Lead sponsor	University of Exeter
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	19
Start date	22 March 2018
Primary completion	13 September 2019
Estimated completion	31 January 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

• Protein, calorie and macronutrient controlled diet, derived from either omnivorous or non-animal sources, alongside unilateral resistance exercise, over a three-day period.

Conditions studied

• Aging — all drugs for Aging →
• Sarcopenia — all drugs for Sarcopenia →

Sponsor

University of Exeter

Who can join

Adults 55 to 75, any sex, with Aging or Sarcopenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A hallmark of ageing is loss of skeletal muscle mass and strength (sarcopenia). Sarcopenia is explained, partially, by reduced responsiveness of muscle to dietary protein. This 'anabolic resistance' can be overcome by consuming protein in close proximity to exercise and/or adequate amounts across the day. Consequently, there is momentum for a greater protein RDA for older individuals. Concurrently, there is a need to establish an evidence base for the efficacy of non-animal proteins.

Mycoprotein is a sustainable non-animal derived protein that imposes a significantly lower environmental burden than animal sources. Our previous work suggests that mycoprotein has the potential to support muscle tissue remodelling to a similar extent as animal derived protein sources. The study will employ a deuterium oxide tracer to quantify muscle protein synthesis over a period of three days in response to a vegan diet or animal based diet, alongside daily unilateral resistance exercise in older adults.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A mycoprotein-based high-protein vegan diet supports equivalent daily myofibrillar protein synthesis rates compared with an isonitrogenous omnivorous diet in older adults: a randomised controlled trial.
   Monteyne AJ, Dunlop MV, Machin DJ, Coelho MOC, et al · · 2021 · cited 37× · PMID 33172506 · DOI 10.1017/s0007114520004481