18 and older, any sex, with Vitamin D Deficiency or Cardiomyopathies. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Caspase 2 Enzyme LevelPrimary· during the surgery, an average of 3 hours
Caspase 2 enzyme activity in right atrial specimen measured by with immunohistochemistry staining The positive control and negative control were taken from human lymph node tissue. as for the control tissue a humane lymph node was used. Positivity for active caspase is shown using cytoplasmic staining . the number of apoptotic cells was measure per each high power filed (HPF) under light microscopy.
Group
Value
95% CI
Vitamin D
1.3
± 1.0
Control Group
2.0
± 0.9
Caspase 3 Enzyme Level, an Average of 3 HoursPrimary· during the surgery, an average of 3 hours
Caspase 3 enzyme activity in right atrial specimen measured by with immunohistochemistry staining The positive control and negative control were taken from human lymph node tissue. as for the control tissue a humane lymph node was used. Positivity for active caspase is shown using cytoplasmic staining . the number of apoptotic cells was measure per each high power filed (HPF) under light microscopy.
Group
Value
95% CI
Vitamin D
1.2
± 0.8
Control Group
2.0
± 0.8
Caspase 7 Enzyme LevelPrimary· during the surgery, an average of 3 hours
Caspase 7 enzyme activity in right atrial specimen measured by with immunohistochemistry staining The positive control and negative control were taken from human lymph node tissue. as for the control tissue a humane lymph node was used. Positivity for active caspase is shown using cytoplasmic staining . the number of apoptotic cells was measure per each high power filed (HPF) under light microscopy.
Group
Value
95% CI
Vitamin D
1.3
± 1.0
Control Group
1.8
± 1.2
Interlukin-10 (IL-10) Serum LevelPrimary· Right before the intervention(3 days before surgery)
The concentration of IL-10 in the serum of patients was measured using a quantitative enzyme-linked immunosorbent assay (ELISA) kit .
Background and study aim:
Heart diseases are among the most common causes of death worldwide. A large proportion of deaths are caused by heart attacks (myocardial infarction), where blood flow to the heart is reduced resulting in damage to the heart muscle. If the arteries supplying blood to the heart start to become blocked, Coronary Artery Bypass Grafting (CABG) surgery is a treatment to replace the blocked sections of artery can reduce angina (chest pain). However, CABG surgery has complications, including an increased risk of heart attack. Vitamin D deficiency is thought to be linked to poorer recovery from heart attack and CABG surgery. This study aims to investigate if vitamin D supplementation can reduce injury to the heart following CABG surgery.
Who can participate? Adults with vitamin D deficiency undergoing CABG
What does the study involve? Participants are randomly allocated to one of two groups. Those in the first group receive vitamin D at 3 doses per day for 3 days before surgery. The second group will receive a dummy pill (placebo). Both groups will have standard CABG surgery.
What are the possible benefits and risks of participating? Those in the vitamin D group might benefit from its effects. Vitamin D has few side effects, especially when taken for only a few days.
Where is the study run from? Shahid Modarres Hospital (Iran)
When is the study starting and how long is it expected to run for? September 2017 to January 2019
Who is funding the study? Deputy of Research of Shahid Beheshti School of Medicine
Who is the main contact? Dr Erfan Tasdighi erfan.tasdighi@gmail.com
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Other Shahid Beheshti University of Medical Sciences trials
Trials by the same sponsor.
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shahid Beheshti University of Medical Sciences
Last refreshed: 19 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04323852.