NCT04322201: COPPTRIAHL

Continuous Passive Paracentesis for Intra-abdominal Hypertension

Status unknown NA Last updated 26 March 2020

What this trial tests

NA trial testing continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter in Ascites Hepatic in 60 participants. Status unknown.

Timeline

2 November 2019

Primary endpoint
30 November 2021

31 May 2022

Quick facts

Lead sponsor	Centro Hospitalar de Lisboa Central
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	2 November 2019
Primary completion	30 November 2021
Estimated completion	31 May 2022
Sites	1 location across Portugal

Drugs / interventions tested

• continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter
• Ultrasound-guided intermittent large-volume paracentesis

Conditions studied

• Ascites Hepatic — all drugs for Ascites Hepatic →
• Cirrhosis, Liver — all drugs for Cirrhosis, Liver →
• Hypertension, Intraabdominal — all drugs for Hypertension, Intraabdominal →
• Critical Illness — all drugs for Critical Illness →

Sponsor

Centro Hospitalar de Lisboa Central

Who can join

Adults 18 to 75, any sex, with Ascites Hepatic or Cirrhosis, Liver. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.

Patients will be randomized into intermittent or continuous passive paracentesis and the clinical results of these two strategies for preventing and treating intra-abdominal hypertension will compared.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Intra-abdominal hypertension and abdominal compartment syndrome in the critically ill liver cirrhotic patient-prevalence and clinical outcomes. A multicentric retrospective cohort study in intensive care.
   Pereira R, Buglevski M, Perdigoto R, Marcelino P, et al · · 2021 · cited 17× · PMID 33984016 · DOI 10.1371/journal.pone.0251498
2. Continuous passive paracentesis versus large-volume paracentesis in the prevention and treatment of intra-abdominal hypertension in the critically ill cirrhotic patient with ascites (COPPTRIAHL): study protocol for a randomized controlled trial.
   Pereira RA, Virella D, Perdigoto R, Marcelino P, et al · · 2023 · cited 1× · PMID 37582719 · DOI 10.1186/s13063-023-07541-4
3. ESICM LIVES 2025
   · 2025