NCT04316403 is a NA clinical trial of Er:YAG laser in Class II Division 1 Malocclusion, sponsored by Damascus University.

Who is sponsoring NCT04316403?

NCT04316403 is sponsored by Damascus University.

What drugs are being tested in NCT04316403?

Interventions in NCT04316403: Er:YAG laser.

What condition does NCT04316403 study?

NCT04316403 studies Class II Division 1 Malocclusion, Maxillary Prognathism, Protrusion, Incisor.

Is NCT04316403 still recruiting?

NCT04316403 is currently completed. Last updated 24 March 2020.

Last reviewed 2020-03-24 · How we verify

NCT04316403

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Laser-assisted Flapless Corticotomy in Accelerating Canine Retraction

Completed NA Last updated 24 March 2020

What this trial tests

NA trial testing Er:YAG laser in Class II Division 1 Malocclusion in 18 participants. Completed in 15 September 2017.

Timeline

15 February 2015

Primary endpoint
15 June 2017

15 September 2017

Quick facts

Lead sponsor	Damascus University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	18
Start date	15 February 2015
Primary completion	15 June 2017
Estimated completion	15 September 2017
Sites	1 location across Syria

Drugs / interventions tested

Er:YAG laser

Conditions studied

Class II Division 1 Malocclusion — all drugs for Class II Division 1 Malocclusion →
Maxillary Prognathism — all drugs for Maxillary Prognathism →
Protrusion, Incisor — all drugs for Protrusion, Incisor →

Sponsor

Damascus University

Who can join

Adults 16 to 26, any sex, with Class II Division 1 Malocclusion or Maxillary Prognathism. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Erbium lasers have been suggested to accomplish corticotomy without flap reflection due to their attractive advantages. The current trial aimed to evaluate the efficacy of laser-assisted flapless corticotomy in accelerating orthodontic tooth movement. The secondary aim was to evaluate the patients' responses to laser application. It was postulated that canine retraction after laser-assisted flapless corticotomy would be accomplished within a shorter period compared with the conventional canine retraction method, with no significant degree of pain and discomfort.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Evaluation of the efficacy of laser-assisted flapless corticotomy in accelerating canine retraction: a split-mouth randomized controlled clinical trial.
Jaber ST, Al-Sabbagh R, Hajeer MY. · · 2022 · cited 26× · PMID 33876339 · DOI 10.1007/s10006-021-00963-x
Systematic Review: Is High-Energy Laser Therapy (HELT) With Flapless Corticotomy Effective in Accelerating Orthodontic Tooth Movement?
Shaadouh RI, Hajeer MY, Mahmoud G, Murad RMT. · · 2022 · cited 10× · PMID 35198339 · DOI 10.7759/cureus.22337

Verify or expand the search:

Other trials of Er:YAG laser

Trials testing the same drug.

NCT07297043 — Efficacy of Er:YAG Laser in Removing Impacted Mandibular Third Molars · NA · completed
NCT05166395 — Laser Treated Scars and Optical Coherence Tomography (OCT) · NA · withdrawn
NCT04707924 — Efficacy of Fractional Er:YAG Laser in Lupus Erythematosus Scars · NA · withdrawn
NCT04591418 — A Comparative Clinical Study of Different Caries Removal Techniques in Pediatric Patients · NA · completed
NCT03951636 — Non Surgical Protocol for Treatment of Mucositis · NA · completed

Other Damascus University trials

Trials by the same sponsor.

NCT07532161 — Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery · NA · not yet recruiting
NCT07515612 — The Impact of Valerian and Chamomile on Children's Anxiety in the Dental Clinic. · NA · recruiting
NCT07272798 — Cardiac Self-Efficacy in Patients With Chronic Thromboembolic Pulmonary Hypertension · recruiting
NCT07426523 — Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia. · NA · completed
NCT07366788 — Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04316403 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Damascus University
Last refreshed: 24 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04316403.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing