NCT04313374 is a Phase 4 clinical trial of Morphine PCA 1 mg in Brain Tumors, sponsored by Istanbul University.

Who is sponsoring NCT04313374?

NCT04313374 is sponsored by Istanbul University.

What drugs are being tested in NCT04313374?

Interventions in NCT04313374: Morphine PCA 1 mg, Morphine PCA 0,5 mg, Placebo.

What condition does NCT04313374 study?

NCT04313374 studies Brain Tumors.

Is NCT04313374 still recruiting?

NCT04313374 is currently completed. Last updated 18 March 2020.

Last reviewed 2020-03-18 · How we verify

NCT04313374

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia

Completed Phase 4 Last updated 18 March 2020

What this trial tests

Phase 4 trial testing Morphine PCA 1 mg in Brain Tumors in 90 participants. Completed in 1 August 2018.

Timeline

1 August 2016

Primary endpoint
1 May 2018

1 August 2018

Quick facts

Lead sponsor	Istanbul University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	90
Start date	1 August 2016
Primary completion	1 May 2018
Estimated completion	1 August 2018
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Morphine PCA 1 mg — full drug profile →
Morphine PCA 0,5 mg — full drug profile →
Placebo

Conditions studied

Brain Tumors — all drugs for Brain Tumors →

Sponsor

Istanbul University

Who can join

Adults 16 to 70, any sex, with Brain Tumors. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients. The investigators showed that the use of morphine based patient controlled analgesia prevented moderate to severe postoperative pain in patients undergoing supratentorial craniotomy. Morphine related side effects such as sedation, miosis, respiratory depression, nausea and vomiting produce a general reluctance for their use in neurosurgery. Therefore, all patients were closely observed to detect opioid related side effects in the intensive care unit for 24 hours following surgery in our previous study. The Integrated Pulmonary Index (IPI) is a new tool that calculates respiratory and hemodynamic parameters noninvasively. In the present study the investigators will use different doses of morphine based patient-controlled analgesia and the IPI system to determine more effective and safer morphine dose for postoperative analgesia following supratentorial craniotomy.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Brain Tumors

Currently open trials in the same condition.

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NCT06442748 — Short Versus Long-term Levetiracetam in Brain Tumors · Phase 3 · recruiting
NCT01117168 — Enrollment on the Childhood Cancer Research Network (CCRN) of the Children's Oncology Group · active not recruiting

Other Istanbul University trials

Trials by the same sponsor.

NCT07472946 — Whole-Body Vibration Exercise in Patients With Parkinson's Disease · NA · not yet recruiting
NCT07433894 — Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis · not yet recruiting
NCT07420049 — Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study · not yet recruiting
NCT07415967 — The Effect of a Dual-Task Technique-Based Exercise Program on Clinical Outcomes in Rotator Cuff Related Shoulder Pain · NA · recruiting
NCT07473024 — pEEG-Guided Anesthesia and Behavioral Outcomes in Children · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04313374 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istanbul University
Last refreshed: 18 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04313374.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing