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NCT04312074
Role of PWV on Male LUTS Progression
trial in Lower Urinary Tract Symptoms in 159 participants. Terminated before completion.
20 October 2023
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 159 |
| Start date | 11 May 2020 |
| Primary completion | 20 October 2023 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across Hong Kong |
Conditions studied
- Lower Urinary Tract Symptoms — all drugs for Lower Urinary Tract Symptoms →
Sponsor
Chinese University of Hong Kong
Who can join
Adults 40 to 80, male only, with Lower Urinary Tract Symptoms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Male lower urinary tract symptoms (LUTS) is exceedingly common in the general population. Stereotypically, male LUTS have long been attributed to the prostate. However, recent attention has been directed to the bladder dysfunction as a cause of LUTS. LUTS also shares has a close relationship with cardiovascular diseases (CVD), diabetes and metabolic syndrome. These problems could lead to various end-organ damages, via diverse mechanisms, with central arterial stiffness (CAS) is one of them. Amongst the abundant methods for the measurement of CAS, brachial-ankle Pulse Wave Velocity (baPWV) has been shown to be a simple and an accurate approach and is widely used clinically. From investigators' preliminary work, investigators had shown that baPWV is correlated with the baseline voiding function and voided volume. Investigators postulate that CVD and related diseases would increase CAS, which in turn could cause insult to the urinary bladder. Inevitably, it would lead to bladder dysfunction and LUTS. In the wake of this postulation, a study to investigate the relationship of CAS and the progression of male LUTS is proposed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04312074
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04312074 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 23 January 2024
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