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Impacts of a Combined Berry Extract Supplement on Vascular Function and Oxygen Utility Capacity in Young Adults
NA trial testing Berry extract in Healthy in 18 participants. Completed in 13 June 2019.
| Lead sponsor | University of Nebraska |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | other |
| Enrollment | 18 |
| Start date | 4 November 2018 |
| Primary completion | 29 March 2019 |
| Estimated completion | 13 June 2019 |
| Sites | 1 location across United States |
University of Nebraska
Adults 19 to 35, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Endothelial function was measured using flow-mediated dilation in percents (%). A higher value represents a better outcome. Scale range for endothelial function is approximately 8-12% for healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 11.7 | ± 2.9 |
| Placebo Intake | 8.2 | ± 3.1 |
Systolic blood pressure was measured as millimeters of mercury (mmHg). Higher values represent a worse outcome. Scale range for systolic blood pressure is approximately 110-129 for most healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 110.0 | ± 10.0 |
| Placebo Intake | 112.5 | ± 10.3 |
Diastolic blood pressure was measured as millimeters of mercury (mmHg). Higher values represent a worse outcome. Scale range for systolic blood pressure is approximately 70-79 mmHg for most healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 72.8 | ± 7.0 |
| Placebo Intake | 72.4 | ± 7.4 |
Oxygen utility capacity was measured as tissue saturation index in percent (%). Higher values represent a better outcome. Scale range for tissue saturation index (TSI) is approximately 60-90% for most healthy populations at rest.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 71.5 | ± 10.4 |
| Placebo Intake | 64.3 | ± 24.3 |
Index of fatigue during leg extension exercise. A lower value represents a better outcome. Scale range is \~15 - 35% for most healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 27.4 | ± 11.0 |
| Placebo Intake | 25.0 | ± 8.6 |
Fatigue index was quantified during isokinetic contraction of the participants dominant leg before and after berry extract and placebo intake using an isokinetic dynamometer. Test consisted of mild resistance at 240°/s to induce and measure muscular fatigue. Fatigue index = (initial peak torque - final peak torque)/initial peak torque x 100). A lower value represents a better outcome. Scale range is \~15 - 35% for most healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 24.9 | ± 11.2 |
| Placebo Intake | 24.8 | ± 11.8 |
Total antioxidant capacity assessed from the venous blood (plasma). A higher value represents a better outcome. Scale range is 10 - 20 millimoles per milliliter for most healthy populations.
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 15.8 | ± 9.0 |
| Placebo Intake | 15.0 | ± 8.5 |
Oxygenated hemoglobin was measured in arbitrary units (a.u.). Higher values represent a better outcome. Scale range for oxygenated hemoglobin is \~5-15 a.u. in healthy populations
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | 10.1 | ± 7.1 |
| Placebo Intake | 9.6 | ± 8.1 |
Deoxygenated hemoglobin was measured in arbitrary units (a.u.). Lower values represent a better outcome. Scale range for deoxygenated hemoglobin is \~ - 5-5 in healthy populations
| Group | Value | 95% CI |
|---|---|---|
| Berry Extract Intake | -0.4 | ± 1.3 |
| Placebo Intake | -2.7 | ± 8.7 |
The purpose of this study is to investigate the impacts of a combined berry extract supplement (hawthorn berry, tart cherry, and bromelain extracts) on total antioxidant capacity, endothelial function, blood pressure, oxygen utility capacity, and fatigue index in healthy young adults.
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04312022.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing